How long does Profhilo last?

12 July 2026
Tom van Eijk
The contents of this article is medically checked by: Drs. Tom van Eijk

How long does Profhilo last? The visible effects of Profhilo often last for around six months following an initial treatment course. However, results vary. Some people may notice that the effect fades sooner, while improvements in skin hydration and texture may remain noticeable for longer.

Profhilo is not permanent. The hyaluronic acid is gradually broken down by the body, and the visible improvement usually reduces gradually rather than disappearing suddenly.

An initial course commonly consists of two appointments spaced approximately four weeks apart. A practitioner may then recommend maintenance based on your skin, treatment area and desired outcome.

Compare UK clinics and practitioners offering Profhilo treatment.

How long does Profhilo last?

How long do Profhilo results remain visible?

Profhilo results are often reassessed around six months after the initial course. This is not a fixed expiry date. The duration varies between individuals and cannot be guaranteed before treatment.

The treatment is intended to improve skin quality rather than create a permanent change. As the effect gradually reduces, you may notice:

  • less skin hydration;

  • a reduction in glow;

  • fine lines becoming more noticeable again;

  • a gradual loss of firmness.

Your skin should not suddenly look worse when Profhilo wears off. It continues through its natural ageing process.

Read more about Profhilo treatment.

How does Profhilo work?

Profhilo is an injectable treatment containing stabilised hyaluronic acid. It is mainly used to support skin hydration, elasticity and overall skin quality.

Unlike a traditional dermal filler, Profhilo is not primarily intended to:

  • add volume;

  • reshape facial features;

  • fill one specific deep crease;

  • create a lifting effect comparable with surgery.

It spreads through the treated tissue and is commonly considered for concerns such as dry skin, fine lines, reduced elasticity and mild skin laxity.

The changes are usually subtle. Profhilo should not make the face look noticeably fuller.

Read more about What is profhilo?

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Why can the result last after the product starts breaking down?

The length of the visible result is not the same as the length of time the injected product remains unchanged in the skin.

The hyaluronic acid is gradually processed by the body. During and after this period, the skin may continue to appear better hydrated and smoother.

It is therefore more accurate to discuss how long the visible result lasts rather than how long Profhilo physically “stays” in the skin.

Avoid stating that the entire product disappears within a specific number of weeks. Individual breakdown cannot be measured precisely during an ordinary cosmetic consultation.

When will I see results from Profhilo?

Some people notice improved hydration or a fresher appearance during the first few weeks. Changes in texture and firmness generally develop more gradually.

The final result should not be judged immediately after the first appointment. Profhilo is usually assessed after the initial course has been completed and the skin has had time to settle.

Temporary swelling or small raised areas at the injection points are treatment reactions and should not be confused with the final result.

Read more about when Profhilo results become visible.

Profhilo results timeline

  1. 1 First few days — redness, swelling, bruising or small raised areas may be visible
  2. 2 First few weeks — skin may begin to feel more hydrated
  3. 3 Around four weeks — the second appointment is commonly carried out
  4. 4 Following the second treatment — changes in texture and firmness become easier to assess
  5. 5 After several months — the visible effect may gradually begin to reduce

Why are two Profhilo treatments commonly recommended?

A Profhilo treatment plan often starts with two appointments approximately four weeks apart. The second appointment forms part of the initial course rather than being an early maintenance treatment.

One appointment may produce some improvement, but it may not provide the same result as completing the recommended course.

The practitioner may adjust the plan according to:

  • the area being treated;

  • baseline skin condition;

  • previous treatments;

  • the degree of skin laxity;

  • how the skin responds after the first appointment.

Not everyone requires exactly the same number of appointments.

Read more about how many Profhilo treatments are needed.

What affects how long Profhilo lasts?

There is no reliable formula that predicts the duration for one person. Results may be influenced by a combination of factors, including:

  • baseline skin quality;

  • the severity of skin ageing;

  • the treatment area;

  • the treatment plan used;

  • previous aesthetic treatments;

  • sun exposure and skincare habits;

  • smoking;

  • individual biological variation.

Age alone does not determine how long Profhilo will last. Claims that exercise or a “fast metabolism” will definitely make it wear off quickly should also be treated cautiously.

A consultation provides a more useful estimate than a standard schedule based only on age.

Does Profhilo last less time in mature skin?

Profhilo can be considered for mature skin, but age alone does not determine suitability or results.

People with mild dryness, fine lines or reduced elasticity may notice an improvement in skin quality. However, Profhilo may be less suitable as a stand-alone treatment when the main concern is:

  • marked skin laxity;

  • significant volume loss;

  • deep folds;

  • pronounced jowls;

  • excess skin.

A practitioner may discuss dermal fillers, collagen-stimulating treatments, energy-based procedures or surgical options where appropriate. These treatments have different purposes and risks.

Cosmetic treatment is optional, and combining treatments is not always necessary.

When should Profhilo maintenance be considered?

Maintenance is usually considered when the visible improvement begins to reduce rather than automatically on a fixed date.

Some people arrange a review at around six months. Others may wait longer depending on the result, their preferences and the advice of their practitioner.

A possible treatment journey is:

  • an initial consultation;

  • two treatments approximately four weeks apart;

  • time for the result to develop;

  • a review after several months;

  • maintenance only when appropriate.

Having more frequent treatment does not automatically produce a better result. A practitioner should assess the skin before recommending another appointment.

Profhilo compared with dermal fillers and skin boosters

Profhilo, dermal fillers and skin boosters are injectable treatments, but they are not interchangeable.

Profhilo

Profhilo is mainly used to support hydration, elasticity and general skin quality. It is not designed to create defined facial volume.

Dermal fillers

Dermal fillers are generally used to restore or add volume, soften selected folds or alter facial contours. Their longevity depends on the product, treatment area and individual response.

Hyaluronic acid skin boosters

Skin boosters are primarily used to improve hydration and skin texture. The injection technique, product properties and treatment schedule differ from Profhilo.

Collagen-stimulating treatments

Treatments such as poly-L-lactic acid products are intended to stimulate collagen over time. They have a different treatment process, risk profile and expected duration.

The treatment that lasts longest is not automatically the most appropriate choice. Selection should be based on the concern being treated.

Read more:
Profhilo or dermal fillers

Profhilo compared with Profhilo Structura

Profhilo Structura is not simply a stronger version of standard Profhilo.

Standard Profhilo is mainly associated with skin hydration and quality. Profhilo Structura is designed for use at a different tissue depth and may be considered when changes in facial fat compartments contribute to an aged or hollow appearance.

The products have different treatment purposes and should not be selected solely according to which one is expected to last longer.

A qualified practitioner should assess facial structure, skin quality and volume changes before recommending either treatment.

Read more about Profhilo Structura.

Are there side effects or downtime?

Profhilo injections can cause temporary reactions at the treatment sites. These may include:

  • redness;

  • swelling;

  • tenderness;

  • bruising;

  • itching;

  • small raised areas.

These reactions often improve within a few days, although bruising can take longer to settle.

Your practitioner may advise you to avoid strenuous exercise, excessive heat, alcohol, pressure on the treated area and certain skincare products for a limited period. Follow the personalised aftercare instructions given by your clinic.

Seek medical advice promptly if you develop severe or increasing pain, unusual skin discolouration, spreading redness, marked swelling, visual symptoms or signs of infection.

Read more:
Profhilo side effects

Profhilo before and after photos

Profhilo picture of Dokter Lylian Logtenberg Kliniek (before)
Profhilo picture of Dokter Lylian Logtenberg Kliniek (after)
These pictures are from Dokter Lylian Logtenberg Kliniek
Profhilo picture of Huidkliniek Twente (before)
Profhilo picture of Huidkliniek Twente (after)
These pictures are from Huidkliniek Twente
Profhilo picture of ØSK Clinic (before)
Profhilo picture of ØSK Clinic (after)
These pictures are from ØSK Clinic
Profhilo picture of Prof. Aesthetics (before)
Profhilo picture of Prof. Aesthetics (after)
These pictures are from Prof. Aesthetics
Profhilo picture of Prof. Aesthetics (before)
Profhilo picture of Prof. Aesthetics (after)
These pictures are from Prof. Aesthetics
Profhilo picture of Beautifier Maastricht (before)
Profhilo picture of Beautifier Maastricht (after)
These pictures are from Beautifier Maastricht

What should you look for in Profhilo before-and-after photos?

Before-and-after photographs may help illustrate possible changes in hydration, texture and mild skin laxity. They do not predict an individual result.

When comparing photographs, check whether:

  • the lighting is similar;

  • the person has the same facial expression;

  • the camera position is consistent;

  • the time after treatment is stated;

  • the number of appointments is disclosed;

  • other treatments were carried out at the same time.

Profhilo results are usually subtle. Dramatic lifting or major contour changes may indicate that another treatment was also involved.

Read more about Profhilo before and after.

What affects the cost of Profhilo maintenance?

The cost depends on the clinic, practitioner, treatment area and number of appointments recommended.

Other cost factors can include:

  • whether the appointment is part of an initial course or maintenance;

  • whether more than one area is treated;

  • consultation or review fees;

  • the product and amount used;

  • the practitioner’s qualifications and experience;

  • the clinic’s location.

Do not choose a clinic according to price alone. Check who will perform the treatment, what product will be used, what aftercare is available and how complications are managed.

Read more about Profhilo cost.

Profhilo reviews in the UK

Wonderful experience. Always feel very safe and in good hands. The Botox is really great and I never need a top up. Profhilo is also great and the procedure is done with care. Would 100 percent recommend.
10 July 2026 16:04
I don’t usually leave reviews, but Sonia definitely deserves one. I’ve been going to Sonia for over two years for my Botox treatments, but somehow every visit ends with me having Profhilo, filler, or another treatment too! 😄 What keeps me coming back isn’t just her warm, kind, and lovely personality, it’s her incredible work and the attention to every li... Show more »
I don’t usually leave reviews, but Sonia definitely deserves one.

I’ve been going to Sonia for over two years for my Botox treatments, but somehow every visit ends with me having Profhilo, filler, or another treatment too! 😄

What keeps me coming back isn’t just her warm, kind, and lovely personality, it’s her incredible work and the attention to every little detail. She genuinely cares about achieving the best possible results and never rushes anything.

Once you go to Sonia, you’ll definitely want to go back. I couldn’t recommend her more! Show less »
9 July 2026 18:06
I had Botox and Profhilo treatment with Dr Ramin, and I am extremely happy with the results. Dr Ramin is highly professional, knowledgeable, and made me feel comfortable throughout the entire process. He is very respectful, friendly, and takes the time to explain everything clearly. The treatments were carried out with great care, and the results look natura... Show more »
I had Botox and Profhilo treatment with Dr Ramin, and I am extremely happy with the results. Dr Ramin is highly professional, knowledgeable, and made me feel comfortable throughout the entire process. He is very respectful, friendly, and takes the time to explain everything clearly.
The treatments were carried out with great care, and the results look natural and refreshing. The clinic is spotless, welcoming, and provides an excellent experience from start to finish.
I would highly recommend Dr Ramin and Skin Lab Medispa to anyone looking for high-quality aesthetic treatments. Thank you for the outstanding care and service! 🌟 Show less »
suna hurman
Skin Lab Medispa
23 June 2026 17:05
This is my second review of Diyah Aesthetic clinic. I'd like to correct my previous negative comments due to a misunderstanding. I had my Profhilo treatment today, and it was more than satisfactory. Both the clinic and the injector exude a calming atmosphere, she was very polite, and the treatment was painless. I will be returning for a second session. Thank... Show more »
This is my second review of Diyah Aesthetic clinic. I'd like to correct my previous negative comments due to a misunderstanding. I had my Profhilo treatment today, and it was more than satisfactory. Both the clinic and the injector exude a calming atmosphere, she was very polite, and the treatment was painless. I will be returning for a second session. Thank you. Show less »
16 June 2026 16:04
I’ve had quite a few treatments here and I am a regular (can’t stop coming!) 😁 Treatments I have had include; The Exilis Ultra 360 Emsculpt & Hi EMT (Emsculpt was soo good!) Profhilo Lemon Bottle & Aqualyx (I preferred Aqualyx of the two) Botox I have regularly and I am always pleased with the results. It’s always nice seeing the girls and I always enjoy... Show more »
I’ve had quite a few treatments here and I am a regular (can’t stop coming!) 😁

Treatments I have had include;
The Exilis Ultra 360
Emsculpt & Hi EMT (Emsculpt was soo good!)
Profhilo
Lemon Bottle & Aqualyx (I preferred Aqualyx of the two)
Botox I have regularly and I am always pleased with the results.

It’s always nice seeing the girls and I always enjoy my visits here. I fully recommend. I usually have Laura is really nice, gentle, understandong and highly professional.

Thank again for all my treatments so far! 😊 Show less »
Fjoralba Hysko
Serene Skin & Beauty
7 June 2026 13:01
I recently had Profhilo treatment at this clinic and honestly had such a great experience from start to finish. Emel is professional, welcoming, and made me feel completely comfortable throughout the whole appointment. Everything was explained clearly, including the procedure and aftercare. The clinic itself was spotless. The treatment was quick and handled... Show more »
I recently had Profhilo treatment at this clinic and honestly had such a great experience from start to finish. Emel is professional, welcoming, and made me feel completely comfortable throughout the whole appointment.
Everything was explained clearly, including the procedure and aftercare.
The clinic itself was spotless. The treatment was quick and handled so gently, and I'm already noticing my skin looking more hydrated, smoother, and glowing naturally.
I'm so happy with the results and will definitely be returning for future treatments. Highly recommend this clinic to anyone.
Thank you 🙏 Show less »
Valentina Lazarovska
AesClinica London
28 May 2026 16:04

What happens when Profhilo wears off?

The result normally fades gradually. Your skin does not become dependent on Profhilo, and stopping treatment should not accelerate the natural ageing process.

Over time, you may notice that hydration, glow or firmness returns towards its previous level.

You can then decide whether to:

  • have a maintenance consultation;

  • wait longer;

  • continue with skincare only;

  • discuss a different treatment;

  • have no further cosmetic treatment.

There is no obligation to continue treatment once the initial result has reduced.

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Frequently asked questions about how long Profhilo lasts

How long does Profhilo last?

Is Profhilo permanent?

How many Profhilo treatments are needed?

When will I see the final Profhilo result?

How often should Profhilo be repeated?

Does Profhilo wear off suddenly?

Does exercise make Profhilo wear off faster?

Is Profhilo suitable for people over 50?

Do dermal fillers last longer than Profhilo?

What happens if I stop having Profhilo?

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