What is Rejuran and how does this treatment work?
Rejuran is a skin-rejuvenating injectable containing polynucleotides (PN), small DNA fragments that stimulate the skin’s natural repair process. The treatment is used for fine lines, acne scars, thin or damaged skin, and early signs of skin aging. By stimulating collagen and elastin production, skin quality gradually improves from within.
Because technique, indication, and experience vary per practitioner, it is important to compare carefully. On Injectablesbooking, you can compare clinics in your area and see which qualified and BIG-registered practitioners have experience with Rejuran.
Rejuran uses polynucleotide injections
Suitable for skin aging, fine lines, and scars
Multiple sessions provide a cumulative effect
Comparing helps you choose the right doctor and clinic
Rejuran stimulates skin repair through polynucleotides that promote cell activity and collagen production. The baseline condition of the skin—such as thickness, elasticity, and degree of damage—differs from person to person. When the skin’s regenerative capacity is higher, the tissue responds more efficiently to stimulation. As a result, the degree of visible improvement varies.
Rejuran activates fibroblasts that gradually produce new collagen. Collagen synthesis is a biological process that takes weeks to months. Repeated sessions enhance stimulation and support structural rebuilding. This leads to step-by-step skin improvement.
Superficial skin concerns respond more quickly to biostimulation than deeper structural damage. When the main focus is improving hydration and fine lines, changes become visible sooner. In cases of deeper collagen breakdown, tissue repair takes longer. This explains why the pace of visible results differs.
Price differences arise from variations in the amount of product used, treatment technique, and consultation time. The practitioner’s expertise and clinic operating costs also influence the fee. The total cost is determined by product usage and medical execution. As a result, rates differ between clinics.
Indication, technique, and treatment frequency may vary per clinic. These factors affect effectiveness, safety, and recovery time. Transparency about product quantity and treatment planning determines the final outcome. Therefore, comparing options provides insight into factors that influence results and risk.
Type of treatment: polynucleotide injections
Goal: skin repair and collagen stimulation
Visible results: yes, after multiple sessions
Main success factor: correct dosage and technique
Using fine needles, Rejuran is injected into the dermis (skin layer). The polynucleotides stimulate cells, promote repair, and strengthen the skin structure at its source.
By stimulating fibroblasts, collagen production increases and skin elasticity improves. As a result, fine lines gradually fade and the skin becomes firmer and more even.
No. The effect is cumulative and requires maintenance (multiple sessions).
With a Rejuran treatment, mild side effects may occur such as slight swelling, redness, a bruised sensation, or small bruises around the injection points. These reactions usually resolve on their own within a few days. In rare cases, small bumps or uneven distribution of the product may occur when technique or placement is not optimal. The risk depends less on the product itself and more on proper technique, correct dosage, and knowledge of anatomy. That is why comparing doctors and clinics is important for safety and a natural result.
A less optimally performed treatment may present as temporary skin irregularities, asymmetry, or palpable small lumps. Sometimes the skin may appear temporarily uneven due to swelling or superficial placement. This does not necessarily mean the treatment is unsafe, but rather that the technique or product distribution was not fully balanced. An experienced doctor can assess this and, if necessary, make adjustments.
The number of sessions varies per person and depends on skin condition, age, and treatment goals. Usually, 2 to 4 sessions are recommended with several weeks in between. Rejuran works through skin improvement and collagen stimulation, which makes a treatment course often more effective than a single session. During the consultation, the doctor will create a suitable treatment plan.
The effect of Rejuran becomes visible gradually. In the first weeks, the skin may already feel slightly smoother, but clearer improvement is usually visible after several weeks to months. Because the treatment focuses on skin quality and regeneration, results build up as multiple sessions take place. An evaluation appointment helps to properly assess progress.

Microneedling + Rejuran: improved absorption
Laser therapy + Rejuran: skin structure & collagen
Fillers + Rejuran: volume and skin quality
Skincare programs: enhanced skin repair
Rejuran stimulates natural repair and improves overall skin quality. It is especially effective for:
Fine lines & wrinkles
Thin or dehydrated skin
Scars (e.g. acne)
Poor skin texture
Duration of effect: 2–6 months depending on skin condition and maintenance sessions.
Safety is determined by:
Correct indication
Experience of the doctor
Hygienic practice
Results vary depending on skin type and number of sessions. After the initial sessions, maintenance results can last 2–6 months.
Aftercare:
Avoid intense physical activity for 24 hours
No sauna or extreme heat immediately after treatment
Proper skincare at home
Suitable if:
You want to improve your skin quality
You want to reduce fine lines or scars
You are looking for a non-invasive treatment
Less suitable if:
Pregnant or breastfeeding
Active infection or inflammation
Allergic reactions to any of the components
Comparing helps provide insight into market prices and approach.
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Rejuran vs fillers
Fillers add volume; Rejuran stimulates skin repair and collagen.
Rejuran vs Botox
Botox relaxes muscles; Rejuran improves skin quality without muscle relaxation.
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A Rejuran treatment is a skin-rejuvenating injectable treatment based on polynucleotides (PN), derived from purified salmon DNA. This active ingredient stimulates skin repair, collagen production, and cell renewal from within. Unlike fillers, Rejuran does not add volume but improves overall skin quality. The treatment is often used for fine lines, acne scars, enlarged pores, and dull or sagging skin.
Yes, Rejuran is effective in improving skin structure, elasticity, and overall skin condition. Polynucleotides support the skin’s natural repair process and stimulate collagen production. Initial results are usually visible after two to four weeks. For optimal results, multiple treatments are often recommended. The effect is subtle and natural because the body itself drives the skin improvement.
Rejuran does not cause permanent scars. After the treatment, small injection marks, mild swelling, or redness may be visible, but these usually disappear within one to three days. When Rejuran is used for acne scars, the skin gradually becomes smoother. Improved skin quality typically remains visible for six to twelve months, depending on skin type, age, and lifestyle.
Polynucleotides and fillers have different mechanisms of action. Fillers add volume and directly correct volume loss. Polynucleotides improve skin quality by stimulating collagen and repair processes. The choice depends on the treatment goal and the underlying cause of the concern.
After a full treatment course, results can last several months. Because the effect is based on skin improvement, it gradually fades as natural aging processes continue. The duration varies per individual. Regular maintenance can prolong the effect.
Rejuran is an effective, non-invasive option for skin rejuvenation and improving skin quality by stimulating collagen and repair processes. Thanks to polynucleotide technology, the skin can appear glossier, more resilient, and smoother without adding volume. Because skin type, skin condition, and aesthetic goals vary, comparing clinics, prices, and experiences is important for a safe and natural-looking choice.
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