What is a cosmetic polynucleotide treatment?

A treatment with polynucleotides, sometimes also known as salmon sperm, skin booster DNA injections, or bio-revitalisation with polynucleotides, is a new way to naturally improve and rejuvenate the skin. The goal of this treatment is to restore skin quality, reduce signs of ageing, and give a fresh, healthy appearance.

What are polynucleotides?

Polynucleotides are natural building blocks of DNA and RNA that naturally occur in our bodies. In cosmetic treatments, they are used to hydrate and firm the skin, while stimulating the natural healing and renewal of skin cells. The polynucleotides used in these treatments are completely safe and are broken down by the body.

What does a polynucleotide treatment involve?

A polynucleotide treatment, also known as a salmon filler, is an innovative injectable or skin booster therapy that restores and rejuvenates the skin from within. Polynucleotides are biological molecules derived from salmon DNA, specifically from salmon sperm.

Read more:
What is PhilArt?

How does a polynucleotide treatment work?

During the treatment, polynucleotides are injected into the skin with fine needles. A polynucleotide treatment, sometimes called salmon sperm, is an innovative injectable or skin booster that restores and rejuvenates the skin from within.

Polynucleotides are biological molecules derived from salmon DNA (salmon sperm). The doctor focuses on areas where the skin needs extra support, such as the face, neck, hands, or décolleté.

Treatments around the eyes, for example for dark circles or fine lines, are among the popular PDRN treatments. Usually, 3 to 4 sessions are needed, spaced 2 to 4 weeks apart. Each session lasts about 30 minutes.

What is a PDRN treatment?

Polynucleotides is a complicated word. Many clinics describe this treatment as PN injections, PDRN treatment, biorevitalisers, or nucleotide treatment.

For which skin concerns is this treatment suitable?

This treatment is suitable for:

  • Reducing fine lines and wrinkles

  • Addressing sagging or dull skin

  • Repairing damaged skin, for example due to sun exposure

  • Improving skin texture and tone

  • Hydrating dry or dehydrated skin

The treatment is often recommended for people looking for a natural way to improve their skin without undergoing surgery.

What can you expect from ‘PDRN’?

  • Softer and fuller skin

  • Fewer fine lines and wrinkles

  • A healthy and radiant appearance

Some results are visible after the first treatment, but the full effect usually becomes noticeable after a few weeks.

Is polynucleotide safe?

A treatment with polynucleotides is considered safe for several reasons:

  • Use of natural substances: Polynucleotides are compounds that naturally occur in the body. They support skin cell repair without chemical or synthetic additives.

  • Biocompatibility: Polynucleotides are well tolerated by the body and carry a low risk of allergic reactions or rejection.

  • Clinical studies: Research supports the effectiveness and safety of polynucleotides in skin improvement. Side effects are usually mild and short-lived, such as redness, swelling, or bruising.

  • Treatment by specialists: The procedure is carried out by qualified professionals, which further increases safety.

  • Minimal invasiveness: The treatments do not require surgery and involve a short recovery time, lowering risks compared to invasive procedures.

If you are considering this treatment, discuss your options with a qualified specialist to ensure the right approach for your skin type and needs.

Advantages and disadvantages of a polynucleotide treatment

Advantages:

  • Natural skin improvement without surgery

  • Suitable for almost all skin types

  • Promotes deep hydration and skin repair

Disadvantages:

  • Multiple sessions needed for optimal results

  • Temporary swelling or redness after the treatment

  • Not suitable during pregnancy or for certain medical conditions

Reviews

I visited Hollie for my first (of 3) polynucleotides treatments back in December. Hollie was very friendly and put me straight at ease, she explained all about the treatment I was having done, how it would help my skin and any possible side effects that could occur. The procedure was very professionally done, with constant check ins to make sure I was comfor... Show more »
I visited Hollie for my first (of 3) polynucleotides treatments back in December. Hollie was very friendly and put me straight at ease, she explained all about the treatment I was having done, how it would help my skin and any possible side effects that could occur. The procedure was very professionally done, with constant check ins to make sure I was comfortable through-out. Hollie also checked in outside of my appointments to make sure everything was healing correctly. I would definitely recommend Hollie to anyone wanting to improve their skin/undereyes. I will be using Hollie for further treatments without hesitation. Lovely girl, friendly & very knowledgeable! Thank you xx Show less »
24 February 2026 21:09
Dr Davina and her team are professional, patient and provide outstanding aesthetic services. I highly recommend them for Botox and polynucleotides. I won’t go anywhere else as their standards and service are consistently high.
Before receiving treatment from Leanne I was suffering from dry skin, redness and dark circles under my eyes. Leanne was very clear during my consultation and made a tailored skincare plan. I noticed a dramatic difference with each treatment especially the micro needling and the polynucleotide treatment. My skin looks so much more rejuvenated even months aft... Show more »
Before receiving treatment from Leanne I was suffering from dry skin, redness and dark circles under my eyes. Leanne was very clear during my consultation and made a tailored skincare plan. I noticed a dramatic difference with each treatment especially the micro needling and the polynucleotide treatment. My skin looks so much more rejuvenated even months after having the treatments. No shop bought moisturiser/ skincare products had ever fully cleared my dry skin or corrected my other skin concerns but the products that Leanne recommended and sold to me worked wonders.
Thank you Leanne x Show less »
17 February 2026 15:03
I’m extremely confident that I made the right decision choosing Jamie and his team for my hair transplant. From the very first consultation there was no hard sell—just honest, sensible advice—which immediately put me at ease. On the day itself, everything ran incredibly smoothly. From the moment I arrived, I was constantly checked on and made to feel comfor... Show more »
I’m extremely confident that I made the right decision choosing Jamie and his team for my hair transplant.

From the very first consultation there was no hard sell—just honest, sensible advice—which immediately put me at ease. On the day itself, everything ran incredibly smoothly. From the moment I arrived, I was constantly checked on and made to feel comfortable throughout the entire process.

Jamie personally discussed and designed a sensible, well-planned hairline that focused on what mattered most to me: density. It’s clear that Jamie is a perfectionist at what he does, and that level of care and precision is exactly what you’re paying for.

For anyone who’s on the fence, my advice would be this: you only get one shot at a hair transplant. Protect your donor area, plan sensibly, and make sure a qualified surgeon is carrying out the punches and incisions.

I also want to highlight the two technicians working alongside Jamie on the day—they were highly skilled, friendly, and incredibly reassuring, which made a big difference.

The aftercare has been just as impressive. Any concerns I’ve had have been answered quickly, and medications were sorted without any hassle. This is exactly why I’m glad I chose to have the procedure done in the UK.

I’m really looking forward to seeing how things progress over the coming months and hope to be sharing some great “after” photos on Jamie’s page in around 12 months. I’ve also got polynucleotide treatments scheduled to support scalp repair and nourishment.

Overall, I couldn’t be happier with my decision. Show less »
14 February 2026 16:04
I honestly cannot recommend Alison enough!!! From start to finish, my polynucleotide treatment experience was absolutely amazing. Alison is so knowledgeable, professional, and genuinely caring she took the time to explain everything in detail, answer all my questions, and make sure I felt completely comfortable and confident. The treatment itself was so muc... Show more »
I honestly cannot recommend Alison enough!!! From start to finish, my polynucleotide treatment experience was absolutely amazing. Alison is so knowledgeable, professional, and genuinely caring she took the time to explain everything in detail, answer all my questions, and make sure I felt completely comfortable and confident.

The treatment itself was so much better than I expected, and the results have been incredible. My skin already looks brighter, healthier, and so much more refreshed I’m beyond happy with it! Alison’s technique is so gentle and precise, and you can really tell she’s highly skilled and passionate about what she does.

The whole experience felt so calm and welcoming, and I left feeling excited and looked after. I wouldn’t trust anyone else now! If you’re considering polynucleotides, Alison is 100% the person to go to.

Thank you so much Alison I’m absolutely thrilled with my results! Show less »
12 February 2026 19:07
Thank you Leane for amazing facial treatments ( botox and polynucleotide eyes so far) I am in the hands of greatness when I am in your clinic. Trust you in 100%. Your knowledge, application and attention to detail to treat & beautify your clients utilizing safe & sumptuous products can never be underestimated. We will do much more as decided to buy available... Show more »
Thank you Leane for amazing facial treatments ( botox and polynucleotide eyes so far) I am in the hands of greatness when I am in your clinic. Trust you in 100%. Your knowledge, application and attention to detail to treat & beautify your clients utilizing safe & sumptuous products can never be underestimated. We will do much more as decided to buy available beauty monthly package. Happy 😊 see you soon . Show less »
12 February 2026 17:05
Absolutely fantastic clinic. Tranquil location and feels very relaxed. All of the clinicians are really warm, friendly and helpful with any questions and have been flexible with requests to move appointments of if I’ve been running late. I’m fairly new to the area and so far have had Botox and under eye polynucleotides which I’ve been really happy with, and... Show more »
Absolutely fantastic clinic. Tranquil location and feels very relaxed. All of the clinicians are really warm, friendly and helpful with any questions and have been flexible with requests to move appointments of if I’ve been running late. I’m fairly new to the area and so far have had Botox and under eye polynucleotides which I’ve been really happy with, and when it’s time to get fillers done I’ll be booking here too. Was recommended by a friend and received a loyalty discount at my first appointment. Very happy and highly recommend. Show less »
12 February 2026 15:03
Had full face polynucleotides with Elodie and cannot wait to see the results, she always explain everything through and the benefits of each treatment. Love coming to the clinic to have my procedures done! Highly recommend xx
Sophie Webb
EB Aesthetics
12 February 2026 13:01
Dr Reisalla Verli D is professional and highly knowledgeable in her work. I have had Botox and under-eye Polynucleotides, and she thoroughly explained the downtime, aftercare, and expected treatment outcomes. So far, I have been very happy with my results and look forward to continuing further treatments in the future. The clinic is well maintained and clean... Show more »
Dr Reisalla Verli D is professional and highly knowledgeable in her work. I have had Botox and under-eye Polynucleotides, and she thoroughly explained the downtime, aftercare, and expected treatment outcomes. So far, I have been very happy with my results and look forward to continuing further treatments in the future. The clinic is well maintained and clean, with a great team and an excellent location. Show less »
8 February 2026 08:08
Lucie is incredibly warm, calming and proffesional. I was completely at ease for my polynucleotides treatment after my initial consultation. She took her time to explain the product, how it works and outlined all of the required health and safety information. She listened to me and gave me plenty of time to digest the information and ask questions before we... Show more »
Lucie is incredibly warm, calming and proffesional. I was completely at ease for my polynucleotides treatment after my initial consultation. She took her time to explain the product, how it works and outlined all of the required health and safety information. She listened to me and gave me plenty of time to digest the information and ask questions before we proceeded.

For the treatment, her care and attention was absolutely fantastic. I felt calm and settled. I was totally numb and barely felt anything, but was given a little stress ball to squeeze which really helped! Out of all three treatments i only had one tiny bruise on one occasion which was easily covered by concealer. I'll definitely be back for my top ups.

Thank you for my brilliant results! Show less »
6 February 2026 21:09
I had a polynucleotide facial with Dr Glow a few weeks ago. Kajal was so lovely and knowledgable, she explained the procedure and aftercare thoroughly. I am super happy with my results!
Alex Paz
Dr Glow
6 February 2026 15:03
I’ve been seeing Sol and Dr. Sam for my Botox and polynucleotides over the past six months, and they truly do an outstanding job. They’re incredibly friendly, knowledgeable, and professional, and I’ve always felt well looked after. I’m consistently happy with the results and would highly recommend this clinic.
4 February 2026 18:06
I had Botox, polynucleotide, and Profhilo treatments, and I couldn't be happier with the results. I highly recommend Shima, she was incredibly patient, especially since I'm not a fan of needles. I barely felt anything during the procedure, and it was very comfortable.
3 February 2026 20:08
Had polynucleotide treatment for my face and neck plus Profhilo at Chelsea Look Aesthetics. My skin is plumper, firmer, and radiant. The practitioner was professional, knowledgeable, and attentive. Highly recommend for facial rejuvenation, skin boosters, and anti-aging treatments!
3 February 2026 11:11
I’ve had several treatments with Sandra at SV clinic, including laser facials and polynucleotides, and the results have been fantastic. My skin has improved significantly, and I’ve felt confident and well looked after at every visit. Sandra is extremely knowledgeable, takes the time to explain everything clearly, and creates a calm, comfortable environment.... Show more »
I’ve had several treatments with Sandra at SV clinic, including laser facials and polynucleotides, and the results have been fantastic. My skin has improved significantly, and I’ve felt confident and well looked after at every visit.

Sandra is extremely knowledgeable, takes the time to explain everything clearly, and creates a calm, comfortable environment. Appointments are always professional but relaxed, which makes the whole experience very enjoyable.

I wouldn’t hesitate to recommend this clinic to anyone considering advanced skin treatments. Show less »
Elaine Hickson
SV Aesthetic Clinic
1 February 2026 21:09
I couldn't recommend Gerrards cross skin clinic enough. Ive had a series of skinpen microneedling and peels, which have worked so well. I spent many years having facias that were just a waste and since seeing Joaty the past few months my skin has improved so much. I have also have a non-surgical rhinoplasty and polynucleotides from Dr Basi and they were just... Show more »
I couldn't recommend Gerrards cross skin clinic enough. Ive had a series of skinpen microneedling and peels, which have worked so well. I spent many years having facias that were just a waste and since seeing Joaty the past few months my skin has improved so much.
I have also have a non-surgical rhinoplasty and polynucleotides from Dr Basi and they were just as incredible as the facials.
Dont waste money elsewhere go with the professionals working with medical grade products and providing medial grade services.
Cant thank Joaty enough! Show less »
31 January 2026 20:08
I’m currently having ongoing Polynucleotide treatment with Andrea and couldn’t be happier with the experience. She is such a warm, lovely lady who immediately put me at ease. Andrea is extremely informative and professional, always taking the time to explain everything clearly and answer any questions. I always feel safe, comfortable, and well cared for in h... Show more »
I’m currently having ongoing Polynucleotide treatment with Andrea and couldn’t be happier with the experience. She is such a warm, lovely lady who immediately put me at ease. Andrea is extremely informative and professional, always taking the time to explain everything clearly and answer any questions. I always feel safe, comfortable, and well cared for in her hands, and I wouldn’t hesitate to recommend her. Show less »
Maxine Hammond
Iris Aesthetics Ltd
31 January 2026 15:03
I’ve been a client of Yuliya at Novello Skin for over 15 years and have had a wide variety of treatments during that time. She’s professional, friendly and incredibly knowledgeable, offering a full range of treatments including Botox, fillers, polynucleotides, skin boosters, lip treatments, volume work, microneedling, threads and many more treatments for the... Show more »
I’ve been a client of Yuliya at Novello Skin for over 15 years and have had a wide variety of treatments during that time. She’s professional, friendly and incredibly knowledgeable, offering a full range of treatments including Botox, fillers, polynucleotides, skin boosters, lip treatments, volume work, microneedling, threads and many more treatments for the face and body.
Every appointment includes a thorough consultation, and treatments are always tailored to your individual needs. Yuliya will often recommend specific areas or even a course of treatments to make sure you get the best possible results. She also has a great sense of humour that helps you feel completely at ease - even when needles are involved! The results are always natural-looking and beautifully done. A truly bespoke and reassuring experience every visit. Show less »
Hayley Gillert
Novello Skin
31 January 2026 09:09
I had my treatment with Dr Negar. I was a bit anxious but when I went, she made me feel so calm and was very professional. I recommend the polynucleotide sessions with her. My skin feels amazing, loved every second 😍😍
pajhan Yeganeh
CLNQ Manchester
30 January 2026 21:09
2026 just started and I already made one of the best decisions of the year by starting treatments here. I started with a free consultation with Dr Ravinder who is so insightful and patient, and we worked out a plan for 11s and masseter Botox, 1ml under-eye filler, and 3 under-eye polynucleotides sessions. Dr Ravinder completed the Botox treatments on the sp... Show more »
2026 just started and I already made one of the best decisions of the year by starting treatments here. I started with a free consultation with Dr Ravinder who is so insightful and patient, and we worked out a plan for 11s and masseter Botox, 1ml under-eye filler, and 3 under-eye polynucleotides sessions.

Dr Ravinder completed the Botox treatments on the spot, and she was super gentle, and the process was painless and meticulous. She recommended Suzanne to me for the under-eye therapies and reception quickly arranged for me to meet with her within 2 days.

Suzanne is another masterful clinician, very experienced, professional and fun. It was my first time getting under-eye filler and I was a little nervous but I was taken care of very well and the process was once again over before I knew it and the results were just perfect. I’ve also had my first under-eye polynucleotides sessions and I am also extremely happy with both the procedure and the aftermath.

Both clinicians I have worked with so far have been nothing short of great and I’m really looking forward to continuing these and other therapies here. The reception staff is also really lovely and accommodating and the clinic itself is spotless and comfortable.

In terms of pricing, it is very reasonable considering the quality of materials, the reputation of this treatment centre, its ideal city centre location and the experience of the clinicians. Several payment plans are available as well.

If you’re someone who is considering starting or continuing aesthetic or clinical skin treatments, I would recommend you to come to Therapie without hesitation. Show less »
I had polynucleotides for my under-eye area with Dr Kate and the results have been incredible. My dark circles are noticeably lighter, the crepey skin has improved so much and the area looks brighter, tighter and smoother overall. Dr Kate took the time to explain everything clearly and made me feel completely safe and comfortable throughout. The results loo... Show more »
I had polynucleotides for my under-eye area with Dr Kate and the results have been incredible. My dark circles are noticeably lighter, the crepey skin has improved so much and the area looks brighter, tighter and smoother overall.

Dr Kate took the time to explain everything clearly and made me feel completely safe and comfortable throughout. The results look very natural and have made a huge difference to how refreshed I look. I would highly recommend Dr Kate BB to anyone struggling with under-eye concerns and wanting a natural and subtle approach! Show less »
Jennifer Schauerte
Dr Kate BB
29 January 2026 17:05
I had a lovely experience with Lucy for my 1st session of polynucleotide, which was suggested as a procedure on my consultation. Everything was explained all along and Lucy made me feel comfortable during the treatment.
Highly recommend Persona, the place is clean, well kept and they offer a wide array of cosmetic treatments.
I’ve been coming to Therapie Clinic Watford for around 4 years now for my injectable treatments and I genuinely wouldn’t trust anywhere else. The doctors are amazing – always professional, knowledgeable and make you feel completely at ease. The whole team is lovely and so welcoming. I’ve just finished my course of polynucleotides and I am absolutely blown a... Show more »
I’ve been coming to Therapie Clinic Watford for around 4 years now for my injectable treatments and I genuinely wouldn’t trust anywhere else. The doctors are amazing – always professional, knowledgeable and make you feel completely at ease.

The whole team is lovely and so welcoming. I’ve just finished my course of polynucleotides and I am absolutely blown away by the results. My skin looks incredible!

Highly recommend this clinic to anyone considering aesthetic treatments. Show less »
28 January 2026 08:08
I would highly recommend! I had polynucleotides done around my eyes. I have just had my second treatment and honestly I was amazed at the results just from the first treatment! My crows feet have significantly reduced. I was not expecting to see such good results until my 2nd or 3rd one. It’s a very relaxed atmosphere, you feel totally safe and welcomed. The... Show more »
I would highly recommend! I had polynucleotides done around my eyes. I have just had my second treatment and honestly I was amazed at the results just from the first treatment! My crows feet have significantly reduced. I was not expecting to see such good results until my 2nd or 3rd one. It’s a very relaxed atmosphere, you feel totally safe and welcomed. The treatment was not as painful as I expected it to be. The money and the little discomfort you feel is 100% worth the results. Show less »
26 January 2026 12:12
I recently underwent a course of Hyal skin booster treatments combined with Vitaran polynucleotides to help reduce rosacea across my cheeks, forehead and nose, as well to improve dark circles under my eyes and achieve a more refreshed, less tired appearance. Dannii was extremely knowledgeable and friendly, and she offered excellent advice throughout the proc... Show more »
I recently underwent a course of Hyal skin booster treatments combined with Vitaran polynucleotides to help reduce rosacea across my cheeks, forehead and nose, as well to improve dark circles under my eyes and achieve a more refreshed, less tired appearance.
Dannii was extremely knowledgeable and friendly, and she offered excellent advice throughout the process. She explained everything clearly and made the experience comfortable and reassuring.
I would highly recommend these treatments, as I’ve definitely seen effective results and I’ll be returning for further treatments. Show less »
26 January 2026 08:08

FAQ

Is the treatment painful?

How long do the results last?

Are there any risks?

What does a treatment cost?

Which clinics in the United Kingdom offer this treatment?

On Injectablesbooking, you can easily find clinics that offer this treatment. The platform provides an overview of recognised clinics and GMC-registered doctors. Compare clinics based on experience, prices, and reviews to make the best choice.

Compare clinics in London

Promoted
Now being
viewed
Hampstead Aesthetics
Hampstead Aesthetics
London, West End Lane 269
7 km
Botox zone from
£ 180,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 300,00
View profile
Promoted
Now being
viewed
Thérapie Clinic - Marylebone
Thérapie Clinic - Marylebone
London, Wigmore Street
2 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
View profile
Promoted
Now being
viewed
Thérapie Clinic - Westfield Stratford
Thérapie Clinic - Westfield Stratford
London
6 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
View profile
Promoted
Now being
viewed
Thérapie Clinic - Canary Wharf (Cabot Place)
Thérapie Clinic - Canary Wharf (Cabot Place)
London, Cabot Square 1
7 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
View profile
Austin Brewer Facial Aesthetics
Austin Brewer Facial Aesthetics
<1 km
Botox zone from
-
Filler per ml from
-
Profhilo per 2 ml from
-
View profile
Derm Design - Chelsea
Derm Design - Chelsea
<1 km
Botox zone from
-
Filler per ml from
-
Profhilo per 2 ml from
-
View profile
Alcove Aesthetics by Dr Goziem
Alcove Aesthetics by Dr Goziem
London, Pall Mall 120
<1 km
Botox zone from
£ 180,00
Filler per ml from
£ 350,00
Profhilo per 2 ml from
£ 300,00
View profile
The Catalyst Clinic
The Catalyst Clinic
London, Pall Mall 120
<1 km
Botox zone from
£ 150,00
Filler per ml from
£ 300,00
Profhilo per 2 ml from
£ 300,00
View profile

Why Injectablesbooking.co.uk

All clinics in United Kingdom
Read reviews and compare prices
Compare specialists on experience and quality
Always nearby you