What is a cosmetic polynucleotide treatment?

A treatment with polynucleotides, sometimes also known as salmon sperm, skin booster DNA injections, or bio-revitalisation with polynucleotides, is a new way to naturally improve and rejuvenate the skin. The goal of this treatment is to restore skin quality, reduce signs of ageing, and give a fresh, healthy appearance.

What are polynucleotides?

Polynucleotides are natural building blocks of DNA and RNA that naturally occur in our bodies. In cosmetic treatments, they are used to hydrate and firm the skin, while stimulating the natural healing and renewal of skin cells. The polynucleotides used in these treatments are completely safe and are broken down by the body.

What does a polynucleotide treatment involve?

A polynucleotide treatment, also known as a salmon filler, is an innovative injectable or skin booster therapy that restores and rejuvenates the skin from within. Polynucleotides are biological molecules derived from salmon DNA, specifically from salmon sperm.

Read more:
What is PhilArt?

How does a polynucleotide treatment work?

During the treatment, polynucleotides are injected into the skin with fine needles. A polynucleotide treatment, sometimes called salmon sperm, is an innovative injectable or skin booster that restores and rejuvenates the skin from within.

Polynucleotides are biological molecules derived from salmon DNA (salmon sperm). The doctor focuses on areas where the skin needs extra support, such as the face, neck, hands, or décolleté.

Treatments around the eyes, for example for dark circles or fine lines, are among the popular PDRN treatments. Usually, 3 to 4 sessions are needed, spaced 2 to 4 weeks apart. Each session lasts about 30 minutes.

What is a PDRN treatment?

Polynucleotides is a complicated word. Many clinics describe this treatment as PN injections, PDRN treatment, biorevitalisers, or nucleotide treatment.

For which skin concerns is this treatment suitable?

This treatment is suitable for:

  • Reducing fine lines and wrinkles

  • Addressing sagging or dull skin

  • Repairing damaged skin, for example due to sun exposure

  • Improving skin texture and tone

  • Hydrating dry or dehydrated skin

The treatment is often recommended for people looking for a natural way to improve their skin without undergoing surgery.

What can you expect from ‘PDRN’?

  • Softer and fuller skin

  • Fewer fine lines and wrinkles

  • A healthy and radiant appearance

Some results are visible after the first treatment, but the full effect usually becomes noticeable after a few weeks.

Is polynucleotide safe?

A treatment with polynucleotides is considered safe for several reasons:

  • Use of natural substances: Polynucleotides are compounds that naturally occur in the body. They support skin cell repair without chemical or synthetic additives.

  • Biocompatibility: Polynucleotides are well tolerated by the body and carry a low risk of allergic reactions or rejection.

  • Clinical studies: Research supports the effectiveness and safety of polynucleotides in skin improvement. Side effects are usually mild and short-lived, such as redness, swelling, or bruising.

  • Treatment by specialists: The procedure is carried out by qualified professionals, which further increases safety.

  • Minimal invasiveness: The treatments do not require surgery and involve a short recovery time, lowering risks compared to invasive procedures.

If you are considering this treatment, discuss your options with a qualified specialist to ensure the right approach for your skin type and needs.

Advantages and disadvantages of a polynucleotide treatment

Advantages:

  • Natural skin improvement without surgery

  • Suitable for almost all skin types

  • Promotes deep hydration and skin repair

Disadvantages:

  • Multiple sessions needed for optimal results

  • Temporary swelling or redness after the treatment

  • Not suitable during pregnancy or for certain medical conditions

Reviews

🌟 5-Star Review 🌟 I visited this salon yesterday for lip filler and a polynucleotide treatment, and I honestly cannot say enough good things about the experience. I have a really bad needle phobia, so I was super nervous going in — but she was absolutely fantastic from start to finish. She was so calm, gentle, and incredibly reassuring. She explained every... Show more »
🌟 5-Star Review 🌟
I visited this salon yesterday for lip filler and a polynucleotide treatment, and I honestly cannot say enough good things about the experience. I have a really bad needle phobia, so I was super nervous going in — but she was absolutely fantastic from start to finish.
She was so calm, gentle, and incredibly reassuring. She explained everything in detail, took her time, and made sure I was comfortable throughout the entire process. I genuinely felt cared for, not rushed, and completely safe in her hands.
The results? AMAZING. My lips look beautifully natural and refreshed, and the polynucleotide treatment has already given my skin such a healthy glow. I can’t believe I was ever scared — she’s changed how I feel about these treatments completely.
Highly recommend for anyone who’s nervous , new to injectables or want the BEST RESULTS come to this GIRL. Professional, talented, and so kind 💉✨ Show less »
Sabreen Eidaroos
Vain Aesthetics & Beauty
18 October 2025 13:01
Finding a trustworthy and reliable aesthetic clinic can be difficult, but I’m so glad I discovered this one, conveniently located in the centre. I visited for a consultation about hair loss and dark circles under my eyes. I met Maria, who was absolutely lovely—very knowledgeable, professional, and skilled. I had PRP treatment for my hair and Polynucleotide... Show more »
Finding a trustworthy and reliable aesthetic clinic can be difficult, but I’m so glad I discovered this one, conveniently located in the centre. I visited for a consultation about hair loss and dark circles under my eyes.

I met Maria, who was absolutely lovely—very knowledgeable, professional, and skilled. I had PRP treatment for my hair and Polynucleotide injections for my under eyes. During the consultation, I also decided to try Morpheus8 on my neck for a more defined and sharper jawline.

All of the treatments went smoothly, and Maria made me feel completely comfortable throughout.
I already noticed baby hair started growing and my neck definitely look tighter!
I trust her expertise and will definitely be coming back again. Highly recommend this clinic and Maria! Show less »
4 October 2025 11:11
I had a great microneedling treatment along with polynucleotides around my eyes. I noticed amazing results and will definitely be back. Highly recommend!
1 October 2025 13:01
I had the Polynucleotides EYES treatment, not only am I so pleased with the treatment itself but, Jessica was an absolute professional (!) It was a pleasure having my treatment done by her; she was quick without the rush, knowledgeable, kind and concise. The beauty room is clean, tidy and inviting and I was seen to with professionalism at the front desk. Up... Show more »
I had the Polynucleotides EYES treatment, not only am I so pleased with the treatment itself but, Jessica was an absolute professional (!)
It was a pleasure having my treatment done by her; she was quick without the rush, knowledgeable, kind and concise.
The beauty room is clean, tidy and inviting and I was seen to with professionalism at the front desk.
Up to date interior which is always welcoming and nice to wait around in.

I look forward to exploring more with Beauty Heaven Hub, Hoddesdon. Show less »
Sophia Kourt
Beauty Heaven Hub
1 October 2025 08:08
I recently visited Omniya Clinic for a polynucleotide treatment and had a fantastic experience from start to finish. I was treated by Dr. Mariam, who was incredibly friendly, approachable, and made me feel completely at ease throughout. The treatment itself was surprisingly quick and relatively pain-free. The clinic was clean, modern, and the staff were ext... Show more »
I recently visited Omniya Clinic for a polynucleotide treatment and had a fantastic experience from start to finish. I was treated by Dr. Mariam, who was incredibly friendly, approachable, and made me feel completely at ease throughout.

The treatment itself was surprisingly quick and relatively pain-free. The clinic was clean, modern, and the staff were extremely helpful.

A big thank you to Dr. Mariam and the team for such a positive experience. Highly recommended. Show less »
Tatiana Rocha
Omniya Clinic
30 September 2025 07:07
I had radio frequency micro needling approximately 12 months ago and I was very pleased with the results. Since then I've been having polynucleotides, profhilo and Botox with Janine. My skin has never looked or felt so good! I feel like it's taken "years off". Thank you so much!
28 September 2025 16:04
I just had my first polynucleotide session with Alisha, and she immediately put me at ease. From the start, the appointment felt warm and personable, like I had known her for years. Any anxieties I had quickly disappeared. She provided some helpful tools to manage the small sharp sensations, which made a big difference, and our lovely chats throughout the se... Show more »
I just had my first polynucleotide session with Alisha, and she immediately put me at ease. From the start, the appointment felt warm and personable, like I had known her for years. Any anxieties I had quickly disappeared. She provided some helpful tools to manage the small sharp sensations, which made a big difference, and our lovely chats throughout the session were a great distraction. Overall, it was a very positive experience, and I’m looking forward seeing the results! Show less »
27 September 2025 16:04
I’ve recently had a couple of treatments from Jo at JD aesthetics, Jo is helping me turn back time. I’ve so far had two sessions of polynucleotides, as well as micro needling and a chemical peel. All treatments have been fantastic. People can’t quite place what’s different but I’m apparently glowing / looking really well and that’s what I wanted. Jo is extre... Show more »
I’ve recently had a couple of treatments from Jo at JD aesthetics, Jo is helping me turn back time.
I’ve so far had two sessions of polynucleotides, as well as micro needling and a chemical peel. All treatments have been fantastic.
People can’t quite place what’s different but I’m apparently glowing / looking really well and that’s what I wanted.
Jo is extremely professional, knowledgeable and informative, my smile lines are so much smoother, this picture is just one session of polynucleotides, I’ve just had the second one so will see those results in a few weeks and I can’t wait for session 3 of polynucleotides to continue with my “death becomes her, aging backwards make over” 🤣 the 70s kids will get the reference. Thanks Jo! Show less »
24 September 2025 19:07
My experience with Dr. Haus was truly exceptional! From the initial consultation to the final results, every step of my treatment journey was phenomenal. I opted for a combination of Ultherapy Prime, CO2 laser, and polynucleotides to rejuvenate my face and neck. Dr. Haus's expertise and personalized approach made me feel confident and comfortable throughout... Show more »
My experience with Dr. Haus was truly exceptional! From the initial consultation to the final results, every step of my treatment journey was phenomenal. I opted for a combination of Ultherapy Prime, CO2 laser, and polynucleotides to rejuvenate my face and neck. Dr. Haus's expertise and personalized approach made me feel confident and comfortable throughout the process.

The treatments themselves were surprisingly comfortable, and Dr. Haus's team was attentive and caring. The results exceeded my expectations – my skin looks smoother, tighter, and more radiant than ever! I'm so grateful for Dr. Haus's professionalism and artistry.

If you're considering advanced skincare treatments, I highly recommend Dr. Haus. His dedication to delivering outstanding results and exceptional patient care is evident in every aspect of his practice. I'm thrilled with my new look and feel!
Thank you again Dr Haus and all his team. Looking forward to seeing you all soon. Show less »
jose alberto usua innes
Dr Haus Dermatology
23 September 2025 19:07
Highly recommended Dr NG Aesthetics. I went to Nicola for some advice first with the intention of getting anti-wrinkle injections. I had botox at other places in the past and had too much and didn’t love the results. Nicola is so knowledgeable and put me at ease and made a plan to go subtle and add more if needed, we did this & absolutely love the results, w... Show more »
Highly recommended Dr NG Aesthetics. I went to Nicola for some advice first with the intention of getting anti-wrinkle injections. I had botox at other places in the past and had too much and didn’t love the results. Nicola is so knowledgeable and put me at ease and made a plan to go subtle and add more if needed, we did this & absolutely love the results, will be heading back for polynucleotide treatment soon.
The environment is really welcoming, relaxing & comfortable too! Show less »
23 September 2025 10:10
I had my first Polynucleotide Eye Area treatment and honestly feel that it's taken 5 years off!

Absolutely loving the results!

Austin always manages to put me at ease too, as I'm squeamish with needles.

The whole team are lovely too.

I would absolutely recommend Dash Asthetics ❤️😁.
Rachael Light
Dash Aesthetics
22 September 2025 20:08
I was a little nervous before my polynucleotide treatment because I knew it involved multiple small injections. Honestly, the anticipation was worse than the reality. Dr Hana explained everything clearly and used numbing cream, which really helped. I could feel a few tiny pinches here and there, but nothing unbearable, more like little scratches rather than... Show more »
I was a little nervous before my polynucleotide treatment because I knew it involved multiple small injections. Honestly, the anticipation was worse than the reality. Dr Hana explained everything clearly and used numbing cream, which really helped. I could feel a few tiny pinches here and there, but nothing unbearable, more like little scratches rather than big jabs.
During the treatment, the sensation was a bit odd in some areas (especially where the skin is thinner), but it was over surprisingly quickly. Afterwards, I had some small bumps and redness where the needles went, but settled down after a few hours.
Dr Hana was amazing at this treatment and I will defiantly be going back to her for anything else I might want doing in the future. Show less »
Vicky Williams
Dr Hana Aesthetics
20 September 2025 06:06
I am thrilled with the results of my recent treatment with Gavin. I had some hyperpigmentation which he treated with 3 sessions of polynucleotides and the improvement is very noticeable. Gavin is friendly and professional. I highly recommend the Private Skin Company.
Cherie Rhodes Rollason
The Private Skin Company
19 September 2025 16:04
I had Botox, polynucleotide injections, skin peels and fillers with Jess, and the whole experience was wonderful. From start to finish, I felt really well informed and completely at ease. Jess is a nurse and that really shines through — she always put my wellbeing first, explained everything clearly, and made sure I was comfortable throughout. The results a... Show more »
I had Botox, polynucleotide injections, skin peels and fillers with Jess, and the whole experience was wonderful. From start to finish, I felt really well informed and completely at ease. Jess is a nurse and that really shines through — she always put my wellbeing first, explained everything clearly, and made sure I was comfortable throughout.

The results are amazing, and I’m already looking forward to my next appointment. I can only give 5 stars here, but I would happily give 10! I would highly recommend Jess to anyone considering treatment — she’s professional, caring, and genuinely brilliant at what she does. Show less »
18 September 2025 18:06
I recently had my polynucleotide treatment with Nurse Mel, and I couldn’t be happier with the experience. From the moment I arrived, she made me feel comfortable and reassured, explaining everything clearly and answering all of my questions with patience and professionalism. The treatment itself was carried out with such care and precision — I felt complete... Show more »
I recently had my polynucleotide treatment with Nurse Mel, and I couldn’t be happier with the experience. From the moment I arrived, she made me feel comfortable and reassured, explaining everything clearly and answering all of my questions with patience and professionalism.

The treatment itself was carried out with such care and precision — I felt completely at ease in her hands. Nurse Mel has a gentle touch and a warm, friendly manner that makes the whole process so much easier.

I would highly recommend Nurse Mel to anyone considering polynucleotide treatments — she is knowledgeable, skilled, and genuinely cares about her patients. Show less »
18 September 2025 13:01
I've attended Restore Skin for a year now as I recently moved close by. When researching a clinic I saw that Restore Skin and Louise had consistent 5 Star reviews which instilled confidence when choosing a place for Hydrafacials and other beauty treatments. Louise has always been super helpful in recommending treatments, recommending products and even advice... Show more »
I've attended Restore Skin for a year now as I recently moved close by. When researching a clinic I saw that Restore Skin and Louise had consistent 5 Star reviews which instilled confidence when choosing a place for Hydrafacials and other beauty treatments. Louise has always been super helpful in recommending treatments, recommending products and even advice for treatments that she felt I did not need when asked. I regularly get the Hydrafacial which makes my skin feel incredible after, and have had polynucleotides injected under my eye area (which last for around 9 months). The products recommended finally cleared up my acne caused by stress which I cannot thank Louise enough for. Regularly get told off for not religiously applying SPF on daily, however, I will let that slide 🤣 Show less »
Jasmine Janda
Restore Skin
18 September 2025 11:11
I recently had the pleasure of trying the polynucleotide and the 70 Hyal protocol), and I'm absolutely thrilled with the results! My skin feels smoother, more hydrated, and looks radiant. The treatments have helped to improve my skin's texture and tone, and I've also noticed a significant lightening of my pigmentation issues. I'm so impressed with the outcom... Show more »
I recently had the pleasure of trying the polynucleotide and the 70 Hyal protocol), and I'm absolutely thrilled with the results! My skin feels smoother, more hydrated, and looks radiant. The treatments have helped to improve my skin's texture and tone, and I've also noticed a significant lightening of my pigmentation issues. I'm so impressed with the outcome that I'd highly recommend these treatments to anyone looking to rejuvenate their skin.

The professionalism of the practitioner was top-notch, and the treatment environment was spotless and welcoming. From start to finish, I felt comfortable and well-cared for. Can't wait to see how my skin continues to glow! Five stars isn't enough – I'd give it more if I could! Show less »
Survet Tasweer
DermaVqm
17 September 2025 21:09
I had the most beautiful experience having my Polynucleotide and NCTF treatment. From the moment I arrived, the space felt so calming and peaceful, i can see that so much love and care has gone into creating that environment. Sofia was incredibly gentle with every step of the treatment, constantly checking in and making sure I felt comfortable. Throughout t... Show more »
I had the most beautiful experience having my Polynucleotide and NCTF treatment. From the moment I arrived, the space felt so calming and peaceful, i can see that so much love and care has gone into creating that environment. Sofia was incredibly gentle with every step of the treatment, constantly checking in and making sure I felt comfortable.

Throughout the entire appointment, Sofia was so nurturing, thoughtful, and completely personal. She has a really soft energy and was genuinely lovely to talk to throughout, which made me feel relaxed and safe in her hands.

I can tell she truly cares about both the results and your overall well-being, which is so rare to find. I’m honestly so grateful to have found her and would recommend her to absolutely anyone ♥️ Show less »
13 September 2025 17:05
I recently had the Polynucleotide and PRF under-eye treatment with Monika at Estellia Harmony, and the experience was outstanding. Monika explained every step thoroughly, ensuring I felt informed and comfortable throughout. Her attention to detail and expertise are exceptional, and the results have been nothing short of remarkable. I highly recommend Estelli... Show more »
I recently had the Polynucleotide and PRF under-eye treatment with Monika at Estellia Harmony, and the experience was outstanding. Monika explained every step thoroughly, ensuring I felt informed and comfortable throughout. Her attention to detail and expertise are exceptional, and the results have been nothing short of remarkable. I highly recommend Estellia Harmony to anyone considering advanced aesthetic treatments. Show less »
mittal Rathava
Estellia Aesthetic
12 September 2025 14:02
Absolutely amazing trainer! We had a very informative session on skin boosters and polynucleotides with Gurdeep. She is incredibly knowledgeable and passionate about her work. The session started with a thorough explanation of the skin anatomy which really helped lay the foundation before moving on to treatments. Gurdeep made the training engaging and easy... Show more »
Absolutely amazing trainer!
We had a very informative session on skin boosters and polynucleotides with Gurdeep.

She is incredibly knowledgeable and passionate about her work. The session started with a thorough explanation of the skin anatomy which really helped lay the foundation before moving on to treatments.

Gurdeep made the training engaging and easy to follow. No question was too small and she was patient, clear, and more than happy to repeat or expand on anything we needed. She was relatable which made the whole experience enjoyable and confidence-boosting.

We left the session feeling well-informed and much more confident. We will definitely be returning for more training in the future.

Hiral & Shilpa Show less »
Shilpa Patel
AG Clinic
11 September 2025 18:06
I would highly recommend using Hava Aesthetics for face treatments. Dr Hadeel is highly professional, knowledgable with a lovely reasurring manner. She takes the time to understand your concerns and the treatments recommended are fully explained in terms of what to expect and aftercare. I am really pleased with my decision to have polynucleotide treatment... Show more »
I would highly recommend using Hava Aesthetics for face treatments. Dr Hadeel is highly professional, knowledgable with a lovely reasurring manner. She takes the time to understand your concerns and the treatments recommended are fully explained in terms of what to expect and aftercare. I am really pleased with my decision to have polynucleotide treatment with Dr Hadeel as she genuinely cares and I felt very safe and comfortable during the sessions so thank you:) Show less »
Karen Francis
HAVA Aesthetics
10 September 2025 19:07
10/10 experience. The clinic was lovely and very easy to find. Arek, Terry and Olivia were so attentive and knowledgeable, and I can already see such a difference in my under eyes after my first session of polynucleotides. Thank you so much!😊
10 September 2025 17:05
Thank you so much Jo. I am so pleased with my polynucleotide treatment. My skin is absolutely glowing. You are so clever and knowledgeable and a lovely person to go with it. Xxx
Helen Collacott
Jo Ferriday Aesthetics
9 September 2025 19:07
When I have been for a treatment with Tracey I always come out feeling relaxed and happy. I regard her as a friend and I am 100% happy with everything she does. She takes great care with my treatments whether it is fibroblast, polynucleotides, tattoos etc. She will listen and do her utmost to leave her clients happy. Her costs are very reasonable. Go on give... Show more »
When I have been for a treatment with Tracey I always come out feeling relaxed and happy. I regard her as a friend and I am 100% happy with everything she does. She takes great care with my treatments whether it is fibroblast, polynucleotides, tattoos etc. She will listen and do her utmost to leave her clients happy. Her costs are very reasonable.
Go on give yourself a treat or two. It's worth it. Show less »
9 September 2025 18:06
My friends recommended Fiona when I was looking to have Botox done, and I was honestly a bit nervous at first. Fiona instantly made me feel so comfortable and reassured throughout the whole process. I’m now a loyal client and recently had a polynucleotide treatment too — my skin has never looked or felt better! Fiona is professional, caring, and truly amazin... Show more »
My friends recommended Fiona when I was looking to have Botox done, and I was honestly a bit nervous at first. Fiona instantly made me feel so comfortable and reassured throughout the whole process. I’m now a loyal client and recently had a polynucleotide treatment too — my skin has never looked or felt better! Fiona is professional, caring, and truly amazing at what she does. Highly recommend Future Beauty with Fiona! Show less »
Lazaros Fatseas
Future Beauty Leeds
8 September 2025 17:05

FAQ

Is the treatment painful?

How long do the results last?

Are there any risks?

What does a treatment cost?

Which clinics in the United Kingdom offer this treatment?

On Injectablesbooking, you can easily find clinics that offer this treatment. The platform provides an overview of recognised clinics and GMC-registered doctors. Compare clinics based on experience, prices, and reviews to make the best choice.

Compare clinics in London

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Thérapie Clinic - Marylebone
Thérapie Clinic - Marylebone
London, Wigmore Street
2 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
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Thérapie Clinic - Westfield Stratford
Thérapie Clinic - Westfield Stratford
London
6 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
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Now being
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Thérapie Clinic - Canary Wharf (Cabot Place)
Thérapie Clinic - Canary Wharf (Cabot Place)
London, Cabot Square 1
7 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
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Derm Design - Chelsea
Derm Design - Chelsea
<1 km
Botox zone from
-
Filler per ml from
-
Profhilo per 2 ml from
-
View profile
Alcove Aesthetics by Dr Goziem
Alcove Aesthetics by Dr Goziem
London, Pall Mall 120
<1 km
Botox zone from
£ 180,00
Filler per ml from
£ 350,00
Profhilo per 2 ml from
£ 300,00
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The Catalyst Clinic
The Catalyst Clinic
London, Pall Mall 120
<1 km
Botox zone from
£ 150,00
Filler per ml from
£ 300,00
Profhilo per 2 ml from
£ 300,00
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Banhidy Clinic
Banhidy Clinic
London, Pall Mall 120
<1 km
Botox zone from
£ 200,00
Filler per ml from
-
Profhilo per 2 ml from
£ 300,00
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Superdrug Aesthetic Clinics
Superdrug Aesthetic Clinics
London
<1 km
Botox zone from
£ 135,00
Filler per ml from
£ 239,00
Profhilo per 2 ml from
-
View profile

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