What is a cosmetic polynucleotide treatment?

A treatment with polynucleotides, sometimes also known as salmon sperm, skin booster DNA injections, or bio-revitalisation with polynucleotides, is a new way to naturally improve and rejuvenate the skin. The goal of this treatment is to restore skin quality, reduce signs of ageing, and give a fresh, healthy appearance.

What are polynucleotides?

Polynucleotides are natural building blocks of DNA and RNA that naturally occur in our bodies. In cosmetic treatments, they are used to hydrate and firm the skin, while stimulating the natural healing and renewal of skin cells. The polynucleotides used in these treatments are completely safe and are broken down by the body.

What does a polynucleotide treatment involve?

A polynucleotide treatment, also known as a salmon filler, is an innovative injectable or skin booster therapy that restores and rejuvenates the skin from within. Polynucleotides are biological molecules derived from salmon DNA, specifically from salmon sperm.

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How does a polynucleotide treatment work?

During the treatment, polynucleotides are injected into the skin with fine needles. A polynucleotide treatment, sometimes called salmon sperm, is an innovative injectable or skin booster that restores and rejuvenates the skin from within.

Polynucleotides are biological molecules derived from salmon DNA (salmon sperm). The doctor focuses on areas where the skin needs extra support, such as the face, neck, hands, or décolleté.

Treatments around the eyes, for example for dark circles or fine lines, are among the popular PDRN treatments. Usually, 3 to 4 sessions are needed, spaced 2 to 4 weeks apart. Each session lasts about 30 minutes.

What is a PDRN treatment?

Polynucleotides is a complicated word. Many clinics describe this treatment as PN injections, PDRN treatment, biorevitalisers, or nucleotide treatment.

For which skin concerns is this treatment suitable?

This treatment is suitable for:

  • Reducing fine lines and wrinkles

  • Addressing sagging or dull skin

  • Repairing damaged skin, for example due to sun exposure

  • Improving skin texture and tone

  • Hydrating dry or dehydrated skin

The treatment is often recommended for people looking for a natural way to improve their skin without undergoing surgery.

What can you expect from ‘PDRN’?

  • Softer and fuller skin

  • Fewer fine lines and wrinkles

  • A healthy and radiant appearance

Some results are visible after the first treatment, but the full effect usually becomes noticeable after a few weeks.

Is polynucleotide safe?

A treatment with polynucleotides is considered safe for several reasons:

  • Use of natural substances: Polynucleotides are compounds that naturally occur in the body. They support skin cell repair without chemical or synthetic additives.

  • Biocompatibility: Polynucleotides are well tolerated by the body and carry a low risk of allergic reactions or rejection.

  • Clinical studies: Research supports the effectiveness and safety of polynucleotides in skin improvement. Side effects are usually mild and short-lived, such as redness, swelling, or bruising.

  • Treatment by specialists: The procedure is carried out by qualified professionals, which further increases safety.

  • Minimal invasiveness: The treatments do not require surgery and involve a short recovery time, lowering risks compared to invasive procedures.

If you are considering this treatment, discuss your options with a qualified specialist to ensure the right approach for your skin type and needs.

Advantages and disadvantages of a polynucleotide treatment

Advantages:

  • Natural skin improvement without surgery

  • Suitable for almost all skin types

  • Promotes deep hydration and skin repair

Disadvantages:

  • Multiple sessions needed for optimal results

  • Temporary swelling or redness after the treatment

  • Not suitable during pregnancy or for certain medical conditions

Reviews

Finding a practitioner you can trust is so important, and Beata is a true professional. Her clinic is absolutely beautiful and has such a professional, welcoming atmosphere that puts you at ease right away. While I’ve had Botox before, I was honestly amazed at the results this time. I have quite deep wrinkles and usually require a significant top-up to see a... Show more »
Finding a practitioner you can trust is so important, and Beata is a true professional. Her clinic is absolutely beautiful and has such a professional, welcoming atmosphere that puts you at ease right away.
While I’ve had Botox before, I was honestly amazed at the results this time. I have quite deep wrinkles and usually require a significant top-up to see a difference, but Beata managed to get it almost perfect after just the first session. She also took the time to explain exactly how polynucleotides work to repair the under-eye area, and the combination has left my skin looking incredibly rejuvenated and refreshed. A 10/10 experience—I wouldn’t go anywhere else! Show less »
8 March 2026 16:04
I came to see Dr Marcus as I was seeing signs of my skin ageing, - loss of elasticity and bounce. After a full consultation (which I highly recommend to anyone considering treatment), my treatments included Polynucleotides and Secret RF. From the very first session, I noticed a difference. My skin felt more hydrated almost immediately. The Secret RF results... Show more »
I came to see Dr Marcus as I was seeing signs of my skin ageing, - loss of elasticity and bounce. After a full consultation (which I highly recommend to anyone considering treatment), my treatments included Polynucleotides and Secret RF.

From the very first session, I noticed a difference. My skin felt more hydrated almost immediately. The Secret RF results have continued to develop over time, and I'm still seeing improvements. My skin texture is smoother, it feels tighter and plumper, and there has been a significant reduction in redness which has been a concern of mine for a long time.

Dr Marcus is professional, knowledgeable, and passionate about what he does. His expertise and technique meant every session was comfortable and seamless. I felt at ease throughout with no issues whatsoever. I'm so glad to have found such a great practitioner and will absolutely be going back. I highly recommend. Show less »
I came for polynucleotides and booked my session with Dr. Wen Sheng L, who was recommended by a friend. I have been a regular client at Thérapie for the past three years, and in my experience many doctors there tend to rush through appointments even when the clinic isn’t busy. Because of this, I often struggled to find a doctor who would take the time to car... Show more »
I came for polynucleotides and booked my session with Dr. Wen Sheng L, who was recommended by a friend. I have been a regular client at Thérapie for the past three years, and in my experience many doctors there tend to rush through appointments even when the clinic isn’t busy. Because of this, I often struggled to find a doctor who would take the time to carefully assess my face and provide the most suitable injection approach.

Dr. Wen Sheng was excellent. He was very patient, the procedure was completely painless, and he took the time to give detailed recommendations on how the polynucleotides should be injected to best suit my facial structure. I really appreciated his professionalism and attention to detail. Show less »
7 March 2026 12:12
I could not have had a better experience with Aaron! He immediately made me feel comfortable; he is very knowledgeable and it was actually really interesting to learn all about my skin and see the problem areas whilst having everything explained to me in a way that I could understand. Aaron was extremely patient and answered any questions I had in detail. I... Show more »
I could not have had a better experience with Aaron! He immediately made me feel comfortable; he is very knowledgeable and it was actually really interesting to learn all about my skin and see the problem areas whilst having everything explained to me in a way that I could understand. Aaron was extremely patient and answered any questions I had in detail. I didn’t at all feel like he was trying to sell me something or get me to spend loads of money with him; you can tell he really cares about his clients and only wants to offer what is actually needed. I went back for a Polynucleotide treatment and again had a 10/10 experience - Aaron took the time to explain everything to me and made sure I knew exactly what was going on. The treatment itself was very quick and nowhere near as painful as I expected, again Aaron made me feel so comfortable and little touches like the music and the stress balls made the whole experience really great. I can’t wait for my next treatment! Thank you Aaron. Show less »
6 March 2026 21:09
Laura is so friendly as well as professional and her treatments are excellent. I highly recommend the polynucleotides treatment for décolletage.
6 March 2026 17:05
I had polynucleotide treatment done here and honestly couldn’t recommend her enough. From the moment I arrived she was so warm, welcoming and professional, which immediately put me at ease. She took the time to explain everything clearly and made sure I felt comfortable throughout the whole treatment. Her attention to detail and care really stood out, and th... Show more »
I had polynucleotide treatment done here and honestly couldn’t recommend her enough. From the moment I arrived she was so warm, welcoming and professional, which immediately put me at ease. She took the time to explain everything clearly and made sure I felt comfortable throughout the whole treatment.
Her attention to detail and care really stood out, and the whole experience felt very relaxed and personal. It’s clear she genuinely cares about her clients and the quality of her work.
I’m so happy with the service and will definitely be returning. If you’re considering treatment, you’re in very safe hands here. Thank you again for such a lovely experience! Show less »
5 March 2026 10:10
Teresa is fabulous, explains everything clearly so there’s no surprises. Her passion, enthusiasm and knowledge leaves you feeling confident.
The skin care and polynucleotides has made such a difference to my skin I feel amazing. Highly recommended so glad I found her!
3 March 2026 19:07
Fantastic experience with Lianne 👏🏻 after years of considering lip filler (and being too nervous from seeing it go wrong) I finally decided to book in with Lianne & I definitely chose the right place!! She was super patient with me, talked me through everything step by step and I’m very happy with the results 😃 I also had polynucleotides done under my e... Show more »
Fantastic experience with Lianne 👏🏻 after years of considering lip filler (and being too nervous from seeing it go wrong) I finally decided to book in with Lianne & I definitely chose the right place!!

She was super patient with me, talked me through everything step by step and I’m very happy with the results 😃

I also had polynucleotides done under my eyes in the same appointment. Lianne is a complete professional in her techniques, and used high strength numbing cream on both areas- I wasn’t in pain and found both treatments very manageable!

Highly recommend for a professional service with natural results 👏🏻 Show less »
kristina mcgrath
Lianne Powell Aesthetics
3 March 2026 10:10
Elizabeth is the best, I’ve been going to her for years now and wouldn’t go anywhere else. She takes time to listen and understand what your wanting and advises on the best way to achieve it. I get Botox, filler & polynucleotides and always come away happy xx
Leah Henderson
BEYOUBYME Aesthetics
2 March 2026 21:09
Starting my polynucleotide journey has honestly been such a positive experience. From the moment I walked in, Sheena made me feel so welcome and completely at ease. I was quite nervous beforehand, but she really took the time to settle my nerves and explain everything clearly. Her knowledge of the treatment is tenfold — she answered all of my questions with... Show more »
Starting my polynucleotide journey has honestly been such a positive experience. From the moment I walked in, Sheena made me feel so welcome and completely at ease. I was quite nervous beforehand, but she really took the time to settle my nerves and explain everything clearly.

Her knowledge of the treatment is tenfold — she answered all of my questions with confidence and made sure I understood each step of the process. It’s so reassuring to be treated by someone who is clearly passionate and highly experienced in what they do.

The studio itself is absolutely beautiful — clean, calming, and such a lovely environment to relax in. I couldn’t have asked for a better first experience, and I’ll definitely be back! Highly recommend to anyone considering starting their polynucleotide journey.

Thank you Sheena xx Show less »
2 March 2026 19:07
I have been to Lee for a variety of different treatments over the years, including polynucleotides,skin boosters, hydromax and lip filler. I am always extremely happy with the results. Lee is so professional,so knowledgeable and so friendly and welcoming and so good at his job. I highly highly recommend Lee and his lovely team. Thank you for always making me... Show more »
I have been to Lee for a variety of different treatments over the years, including polynucleotides,skin boosters, hydromax and lip filler.
I am always extremely happy with the results. Lee is so professional,so knowledgeable and so friendly and welcoming and so good at his job.
I highly highly recommend Lee and his lovely team.
Thank you for always making me feel so good. Show less »
2 March 2026 18:06
Just completed my Polynucleotide and Skin Booster course with Britney and she is so amazing at what she does! The effort and time she gives her students and attention to detail really shows! I've never left a course feeling so confident in what i'm doing... The loveliest lady, teacher and supporter. Gives you all guidance in every aspect, covers all topics a... Show more »
Just completed my Polynucleotide and Skin Booster course with Britney and she is so amazing at what she does! The effort and time she gives her students and attention to detail really shows! I've never left a course feeling so confident in what i'm doing... The loveliest lady, teacher and supporter. Gives you all guidance in every aspect, covers all topics and provides so many clients!! Thankyou so much for teaching me. I will definitely be back🥹🩷 Show less »
1 March 2026 22:10
I'm so impressed with my results from treatments with Nurse Marzie at her clinic! I've had a few sessions for polynucleotides and now for my lips, and I’m always thrilled with the outcome. This time, my lips look so natural and perfectly enhance my features. Thank you, Marzie, for your amazing work!
thecrowstudios
MS Aesthetics Clinic
1 March 2026 19:07
I’ve been seeing Dr Jane Moon at Dr Moon Clinic for around 6 years now, and every single time I leave feeling genuinely impressed. Her attention to detail, precision, and natural aesthetic judgement are second to none. Over the years I’ve had anti-wrinkle injections (Botox) and dermal fillers for my nose and cheeks, and the results have always been subtle, b... Show more »
I’ve been seeing Dr Jane Moon at Dr Moon Clinic for around 6 years now, and every single time I leave feeling genuinely impressed. Her attention to detail, precision, and natural aesthetic judgement are second to none.
Over the years I’ve had anti-wrinkle injections (Botox) and dermal fillers for my nose and cheeks, and the results have always been subtle, balanced and beautifully executed. I consistently look refreshed and well-rested, never “done.” In fact, I honestly look better than I did 10 years ago, and that is entirely thanks to Jane’s skill and expertise.
She takes time to assess your face holistically, explains everything clearly, and never over-treats. What really sets her apart is her refined Korean approach to aesthetics; focusing on skin quality, balance, and natural regeneration rather than obvious volume. The results are elegant, harmonious, and incredibly natural.
If you’re considering any injectables, including Botox, dermal fillers, polynucleotides, or Sculptra, I wouldn’t go anywhere else. Dr Moon Clinic is exceptional and I highly recommend her for subtle, sophisticated results! Show less »
Edoardo Mondelli
Dr Moon Clinic
1 March 2026 13:01
Cynzia honestly helped me, as a hetero man, get over the stigma around having treatments. I take care of myself and my health, so I don’t see why skin should be any different. She made the whole thing feel normal and professional, not weird or over the top. I travel from the other side of London to see her and wouldn’t go anywhere else. We’ve been focusing... Show more »
Cynzia honestly helped me, as a hetero man, get over the stigma around having treatments. I take care of myself and my health, so I don’t see why skin should be any different. She made the whole thing feel normal and professional, not weird or over the top.

I travel from the other side of London to see her and wouldn’t go anywhere else.

We’ve been focusing on natural collagen building — polynucleotides, PRP, exosomes and microneedling. The goal was to improve overall skin quality, soften deeper smile lines and help with puffy eyes, all in a natural way that upgrade your baseline permanently.

The results have been genuinely life changing for my confidence. My skin looks healthier, smoother and less tired, but still completely like me. That’s exactly what I wanted.

If you’re a guy unsure about it, just speak to her. She gets it. Show less »
George Zelonka
Beauti Skin Clinic
28 February 2026 19:07
I honestly can’t recommend her enough! She does my Botox and polynucleotides under the eyes, and the results are always amazing. She’s incredibly knowledgeable, professional, and genuinely cares about choosing the perfect treatment for my skin and individual needs. What I love most is how she always takes the time to assess my face properly and recommend wh... Show more »
I honestly can’t recommend her enough! She does my Botox and polynucleotides under the eyes, and the results are always amazing. She’s incredibly knowledgeable, professional, and genuinely cares about choosing the perfect treatment for my skin and individual needs.

What I love most is how she always takes the time to assess my face properly and recommend what will look natural and balanced — never overdone. On top of that, she’s so warm and friendly, which makes every appointment such a comfortable experience.

I always leave feeling refreshed, confident, and in very safe hands. Truly the best! 💛 Show less »
Agnieszka Witowska
Charlotte Benson Aesthetics
28 February 2026 17:05
I have been seeing Dr Ishrat for my microneedling and polynucleotide treatments and I honestly could not recommend her more. She is incredibly knowledgeable and takes the time to explain every single step of the procedure before and during treatment, which makes such a difference. I always feel fully informed and reassured because she clearly explains what s... Show more »
I have been seeing Dr Ishrat for my microneedling and polynucleotide treatments and I honestly could not recommend her more. She is incredibly knowledgeable and takes the time to explain every single step of the procedure before and during treatment, which makes such a difference. I always feel fully informed and reassured because she clearly explains what she is doing, why she is doing it and what to expect afterwards.

She is also so kind, calm and accommodating. You never feel rushed and she genuinely listens to your concerns and tailors the treatment to your skin. Her approach feels very considered and precise, which makes me trust her completely.

Not only have I seen great results, but the whole experience feels professional and comfortable every time. If you are looking for someone who is skilled, informative and truly cares about her clients, Dr Ishrat is amazing. Show less »
I had the polynucleotide treatment today and found it to be a really relaxing experience. I can’t wait to have the next one. I have been coming to Susie for almost 20 years and can’t praise her highly enough
I can’t recommend Laser4You in Cuckfield enough – absolutely exceptional service every single time! I’ve had microneedling, lipo contrast, skin boosters, polynucleotides, and lots of different facials, and the results have been amazing across the board. Emily is honestly the best. She’s incredibly knowledgeable, super qualified, and really knows her stuff.... Show more »
I can’t recommend Laser4You in Cuckfield enough – absolutely exceptional service every single time! I’ve had microneedling, lipo contrast, skin boosters, polynucleotides, and lots of different facials, and the results have been amazing across the board.

Emily is honestly the best. She’s incredibly knowledgeable, super qualified, and really knows her stuff. She takes the time to explain everything properly and makes you feel completely comfortable and confident in the treatments. Her pricing is also very reasonable for the level of expertise and results you get.

I wouldn’t go anywhere else now – hands down the best clinic around! Show less »
25 February 2026 14:02
I visited Hollie for my first (of 3) polynucleotides treatments back in December. Hollie was very friendly and put me straight at ease, she explained all about the treatment I was having done, how it would help my skin and any possible side effects that could occur. The procedure was very professionally done, with constant check ins to make sure I was comfor... Show more »
I visited Hollie for my first (of 3) polynucleotides treatments back in December. Hollie was very friendly and put me straight at ease, she explained all about the treatment I was having done, how it would help my skin and any possible side effects that could occur. The procedure was very professionally done, with constant check ins to make sure I was comfortable through-out. Hollie also checked in outside of my appointments to make sure everything was healing correctly. I would definitely recommend Hollie to anyone wanting to improve their skin/undereyes. I will be using Hollie for further treatments without hesitation. Lovely girl, friendly & very knowledgeable! Thank you xx Show less »
24 February 2026 21:09
Just got back from another microneedling facial and polynucleotides aesthetic session treatment from Aisha. Absolutely love coming here, it's such a gorgeous, girly space that make you immediately feel relaxed and comfortable. Aisha definitely knows her stuff, she always makes me feel like I've had 100% personalised service. She pays so much attention to my... Show more »
Just got back from another microneedling facial and polynucleotides aesthetic session treatment from Aisha. Absolutely love coming here, it's such a gorgeous, girly space that make you immediately feel relaxed and comfortable.
Aisha definitely knows her stuff, she always makes me feel like I've had 100% personalised service. She pays so much attention to my skin, she explains the whole process and what she is doing step by step. She always takes her time to make sure I'm getting the full benefit of each treatment. My skin looks amazing each time. I would 100% recommend anyone to come here and be pampered and leave feeling like a new woman! Show less »
21 February 2026 17:05
I went to see Dr Ahmed this week for an initial consultation and treatment. He was extremely friendly and knowledgable. What I really liked is that Dr Ahmed assessed my face and gave me a holistic treatment plan including filler, polynucleotides, microneedling and prescription skincare. I felt I was in safe hands and that he knew exactly what he was talking... Show more »
I went to see Dr Ahmed this week for an initial consultation and treatment. He was extremely friendly and knowledgable. What I really liked is that Dr Ahmed assessed my face and gave me a holistic treatment plan including filler, polynucleotides, microneedling and prescription skincare. I felt I was in safe hands and that he knew exactly what he was talking about. He was skilled at placing the filler and the results are subtle, natural but definitely enhancing. He took his time during the consultation and made sure all of my questions were answered. After being to a few aesthetic clinics in my lifetime I really feel that you get what you pay for. If you want true expertise, skill and natural results you need to go to the best of the best and a doctor as well. Thank you Dr Ahmed I can’t wait to see the full results! Show less »
20 February 2026 19:07
I can’t recommend Vanity Point enough! I’ve been coming here for over 2 years now, and the service has been consistently amazing every single time. The clinic is always clean, professional, and has such a welcoming atmosphere. Claudia is absolutely incredible at what she does. She always makes me feel comfortable, talks me through every step, and gives hones... Show more »
I can’t recommend Vanity Point enough! I’ve been coming here for over 2 years now, and the service has been consistently amazing every single time. The clinic is always clean, professional, and has such a welcoming atmosphere. Claudia is absolutely incredible at what she does. She always makes me feel comfortable, talks me through every step, and gives honest advice about what will work best for me and the results are always flawless. Ive had polynucleotide treatments, Botox, and lip filler with her, and I genuinely wouldn’t go anywhere else. The polynucleotides made such a difference to my skin quality, my Botox and filler is always perfectly placed and natural looking. Show less »
20 February 2026 12:12
I recently had Neogen plasma and polynucleotides with Emma and felt completely confident in her care. She was thoughtful, clinically measured, and adjusted the treatment based on how my skin responded in real time. Recovery has been exactly as explained — controlled and predictable — and the aftercare guidance has been excellent. It’s early days for results,... Show more »
I recently had Neogen plasma and polynucleotides with Emma and felt completely confident in her care. She was thoughtful, clinically measured, and adjusted the treatment based on how my skin responded in real time. Recovery has been exactly as explained — controlled and predictable — and the aftercare guidance has been excellent. It’s early days for results, but the experience itself has been first class. Show less »
20 February 2026 07:07
Dr Davina and her team are professional, patient and provide outstanding aesthetic services. I highly recommend them for Botox and polynucleotides. I won’t go anywhere else as their standards and service are consistently high.

FAQ

Is the treatment painful?

How long do the results last?

Are there any risks?

What does a treatment cost?

Which clinics in the United Kingdom offer this treatment?

On Injectablesbooking, you can easily find clinics that offer this treatment. The platform provides an overview of recognised clinics and GMC-registered doctors. Compare clinics based on experience, prices, and reviews to make the best choice.

Compare clinics in London

Promoted
Top rated
Hampstead Aesthetics
Hampstead Aesthetics
London, West End Lane 269
7 km
Botox zone from
£ 180,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 300,00
View profile
Promoted
Top rated
Thérapie Clinic - Marylebone
Thérapie Clinic - Marylebone
London, Wigmore Street
2 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
View profile
Promoted
Top rated
Thérapie Clinic - Westfield Stratford
Thérapie Clinic - Westfield Stratford
London
6 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
View profile
Promoted
Top rated
Thérapie Clinic - Canary Wharf (Cabot Place)
Thérapie Clinic - Canary Wharf (Cabot Place)
London, Cabot Square 1
7 km
Botox zone from
£ 129,00
Filler per ml from
£ 250,00
Profhilo per 2 ml from
£ 259,00
View profile
Austin Brewer Facial Aesthetics
Austin Brewer Facial Aesthetics
<1 km
Botox zone from
-
Filler per ml from
-
Profhilo per 2 ml from
-
View profile
Derm Design - Chelsea
Derm Design - Chelsea
<1 km
Botox zone from
-
Filler per ml from
-
Profhilo per 2 ml from
-
View profile
Banhidy Clinic
Banhidy Clinic
London, Pall Mall 120
<1 km
Botox zone from
£ 200,00
Filler per ml from
-
Profhilo per 2 ml from
£ 300,00
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Superdrug Aesthetic Clinics
Superdrug Aesthetic Clinics
London
<1 km
Botox zone from
£ 135,00
Filler per ml from
£ 239,00
Profhilo per 2 ml from
-
View profile

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