What is a cosmetic polynucleotide treatment?
A treatment with polynucleotides, sometimes also known as salmon sperm, skin booster DNA injections, or bio-revitalisation with polynucleotides, is a new way to naturally improve and rejuvenate the skin. The goal of this treatment is to restore skin quality, reduce signs of ageing, and give a fresh, healthy appearance.
What are polynucleotides?
Polynucleotides are natural building blocks of DNA and RNA that naturally occur in our bodies. In cosmetic treatments, they are used to hydrate and firm the skin, while stimulating the natural healing and renewal of skin cells. The polynucleotides used in these treatments are completely safe and are broken down by the body.
What does a polynucleotide treatment involve?
A polynucleotide treatment, also known as a salmon filler, is an innovative injectable or skin booster therapy that restores and rejuvenates the skin from within. Polynucleotides are biological molecules derived from salmon DNA, specifically from salmon sperm.
Read more:
What is PhilArt?
How does a polynucleotide treatment work?
During the treatment, polynucleotides are injected into the skin with fine needles. A polynucleotide treatment, sometimes called salmon sperm, is an innovative injectable or skin booster that restores and rejuvenates the skin from within.
Polynucleotides are biological molecules derived from salmon DNA (salmon sperm). The doctor focuses on areas where the skin needs extra support, such as the face, neck, hands, or décolleté.
Treatments around the eyes, for example for dark circles or fine lines, are among the popular PDRN treatments. Usually, 3 to 4 sessions are needed, spaced 2 to 4 weeks apart. Each session lasts about 30 minutes.
What is a PDRN treatment?
Polynucleotides is a complicated word. Many clinics describe this treatment as PN injections, PDRN treatment, biorevitalisers, or nucleotide treatment.
For which skin concerns is this treatment suitable?
This treatment is suitable for:
Reducing fine lines and wrinkles
Addressing sagging or dull skin
Repairing damaged skin, for example due to sun exposure
Improving skin texture and tone
Hydrating dry or dehydrated skin
The treatment is often recommended for people looking for a natural way to improve their skin without undergoing surgery.
What can you expect from ‘PDRN’?
Softer and fuller skin
Fewer fine lines and wrinkles
A healthy and radiant appearance
Some results are visible after the first treatment, but the full effect usually becomes noticeable after a few weeks.
Is polynucleotide safe?
A treatment with polynucleotides is considered safe for several reasons:
Use of natural substances: Polynucleotides are compounds that naturally occur in the body. They support skin cell repair without chemical or synthetic additives.
Biocompatibility: Polynucleotides are well tolerated by the body and carry a low risk of allergic reactions or rejection.
Clinical studies: Research supports the effectiveness and safety of polynucleotides in skin improvement. Side effects are usually mild and short-lived, such as redness, swelling, or bruising.
Treatment by specialists: The procedure is carried out by qualified professionals, which further increases safety.
Minimal invasiveness: The treatments do not require surgery and involve a short recovery time, lowering risks compared to invasive procedures.
If you are considering this treatment, discuss your options with a qualified specialist to ensure the right approach for your skin type and needs.
Advantages and disadvantages of a polynucleotide treatment
Advantages:
Natural skin improvement without surgery
Suitable for almost all skin types
Promotes deep hydration and skin repair
Disadvantages:
Multiple sessions needed for optimal results
Temporary swelling or redness after the treatment
Not suitable during pregnancy or for certain medical conditions
Reviews
After extensive research, I chose Amedics Clinic for polynucleotides eyes and felt confident that I was in the best place, where patient safety comes first. Although I was initially anxious, the team were professional, caring, and reassuring throughout.
Dr Ameera was welcoming and informative, and Calli, who carried out my treatment was extremely gentle an...
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After extensive research, I chose Amedics Clinic for polynucleotides eyes and felt confident that I was in the best place, where patient safety comes first. Although I was initially anxious, the team were professional, caring, and reassuring throughout.
Dr Ameera was welcoming and informative, and Calli, who carried out my treatment was extremely gentle and patient with me. I never felt rushed, and all questions were answered clearly.
After three treatments of polynucleotides eyes I noticed improvement: reduced pigmentation, lifted eyelids and my eczema around eyes is now well controlled. This has significantly improved my overall appearance. Thank you to the whole team. Show less »
Dr Ameera was welcoming and informative, and Calli, who carried out my treatment was extremely gentle and patient with me. I never felt rushed, and all questions were answered clearly.
After three treatments of polynucleotides eyes I noticed improvement: reduced pigmentation, lifted eyelids and my eczema around eyes is now well controlled. This has significantly improved my overall appearance. Thank you to the whole team. Show less »
Had Botox and polynucleotide done by Carl! Great at what he does! Made me feel so at ease, back feeling 21 again 🥳 Thank you!
Shania Lola
Wigtox Sculpt And Rejuvenate15 January 2026 10:10
I had an amazing experience with the polynucleotides treatment at this clinic. Dr Lamy is knowledgeable, and made me feel completely comfortable.
The results are very natural, exactly what I wanted. Highly recommend this clinic to anyone looking to improve their skin quality!
The results are very natural, exactly what I wanted. Highly recommend this clinic to anyone looking to improve their skin quality!
Adam Khar
Novo Clinic14 January 2026 13:01
I recently had polynucleotides to treat my under eye area with the lovely Jade, who made me feel completely at ease with her warm and friendly professionalism. Jade was knowledgable and attentive, and ensured I was comfortable throughout my treatment while she worked her magic. I am excited to see the results and looking forward to my second polynucleotide t...
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I recently had polynucleotides to treat my under eye area with the lovely Jade, who made me feel completely at ease with her warm and friendly professionalism. Jade was knowledgable and attentive, and ensured I was comfortable throughout my treatment while she worked her magic. I am excited to see the results and looking forward to my second polynucleotide treatment in a few weeks!
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Charlotte Wadley
CherryBomb Aesthetics13 January 2026 19:07
So happy with my Polynucleotide Course. The results exceeded my expectations. As always Lisa totally puts you at ease and explains the treatment thoroughly giving you the opportunity to discuss any concerns or worries. If this is something you'd thought about having I'd definitely recommend it as it really works - Thanks Lisa x
Andrea Mason
ABL Medical Aesthetics Ltd 8 January 2026 19:07
Now I am in my 30s I wanted to focus on natural results and improving my skin rather than fillers and I’m so glad I found this clinic. From the start, Dr Kate took a very honest, professional approach and recommended skincare and skin treatments instead of unnecessary injectables. I have struggled with acne and uneven skin for a long time and after a persona...
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Now I am in my 30s I wanted to focus on natural results and improving my skin rather than fillers and I’m so glad I found this clinic. From the start, Dr Kate took a very honest, professional approach and recommended skincare and skin treatments instead of unnecessary injectables. I have struggled with acne and uneven skin for a long time and after a personalised skincare plan alongside SkinPen microneedling and polynucleotides, my acne has cleared and my skin looks genuinely amazing. It’s clearer, smoother, more hydrated and has this natural glow I’ve never had before. What I love most is that nothing looks “done” and I just look like a fresher and more confident version of myself. I cannot recommend Dr Kate BB enough!
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Laura Barker
Dr Kate BB 7 January 2026 14:02
I had polynucleotides done on my under eyes a few months back and wanted to write a review because the transformation was unbelievable!! My makeup now goes on more smoothly and I have little to no texture on my under eyes! As someone that swells and bruises easily the down time was only a few hours and I truly believe that’s because the practitioner was sooo...
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I had polynucleotides done on my under eyes a few months back and wanted to write a review because the transformation was unbelievable!! My makeup now goes on more smoothly and I have little to no texture on my under eyes! As someone that swells and bruises easily the down time was only a few hours and I truly believe that’s because the practitioner was soooo gentle with me. Thank you so much!!
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Heather Bell
Dr and Skin 5 January 2026 22:10
Amazing experience at Medcura in Stanmore with Nimi. I had under-eye polynucleotides and the results are great! Such a fresh, natural improvement. Nimi is professional, caring, and clearly very skilled. Highly recommend!
Julia Wachowska
Medcura Clinic 3 January 2026 16:04
I had an excellent experience with Manuela for Botox, fillers, polynucleotides, micro-needling and chemical skin peel. She is incredibly knowledgeable, gentle, and attentive, taking the time to really understand what I wanted and explaining everything clearly. The results are beautifully natural and exceeded my expectations. I felt completely comfortable and...
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I had an excellent experience with Manuela for Botox, fillers, polynucleotides, micro-needling and chemical skin peel. She is incredibly knowledgeable, gentle, and attentive, taking the time to really understand what I wanted and explaining everything clearly. The results are beautifully natural and exceeded my expectations. I felt completely comfortable and confident in her care from start to finish. I highly recommend Manuela to anyone looking for, high-quality aesthetic treatments.
Thank you so much ❤️ Show less »
Thank you so much ❤️ Show less »
Charlotte
Skin&Glow Medics22 December 2025 11:11
I’ve had Botox and Polynucleotides with Fran and she’s so professional and super friendly. I would highly recommend her and I’m looking forward to coming back for more treatments soon!
20 December 2025 19:07
I Started using Nuvo Medi spa this year & I am so glad to have found them. Both Julie & Miley are very knowledgeable & can always answer any questions regarding treatments & what is best for my skin. They have a great range of treatments. I am looking forward to trying some of their microneedling & skin booster courses in the new year , aswell as some more...
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I Started using Nuvo Medi spa this year & I am so glad to have found them. Both Julie & Miley are very knowledgeable & can always answer any questions regarding treatments & what is best for my skin. They have a great range of treatments. I am looking forward to trying some of their microneedling & skin booster courses in the new year , aswell as some more polynucleotides for under my eyes, they have definitely helped improve the fine lines & wrinkles.
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Lisa Brooks
Nuvo Medispa19 December 2025 11:11
I visited Jade for an under-eye polynucleotide treatment and had such a lovely experience. She was warm, friendly, and instantly put me at ease, which made all the difference. The area was numbed perfectly — I didn’t feel a thing and had no bruising at all. Jade truly has the gentlest hands! Thank you for making me feel so welcome — I can’t wait to return fo...
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I visited Jade for an under-eye polynucleotide treatment and had such a lovely experience. She was warm, friendly, and instantly put me at ease, which made all the difference. The area was numbed perfectly — I didn’t feel a thing and had no bruising at all. Jade truly has the gentlest hands! Thank you for making me feel so welcome — I can’t wait to return for my next treatment.
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Annie Stulp
The Art of Skin19 December 2025 09:09
Today was my second visit to oracle clinics.
First time I saw Ness- who assessed me and advised me on a course of treatment to help with my skin pigmentation from years of sun damage. I am currently using a prescribed medical grade skin care and we are planning a skin peel to help correct years of damage.
I’ve known Ness for many years. She is very experienc...
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Today was my second visit to oracle clinics.
First time I saw Ness- who assessed me and advised me on a course of treatment to help with my skin pigmentation from years of sun damage. I am currently using a prescribed medical grade skin care and we are planning a skin peel to help correct years of damage.
I’ve known Ness for many years. She is very experienced in her field and is not afraid to say no to treatments not needed or advised which I respect. She has also done a fantastic job of growing her clinic with the addition of new clinicians and new premises.
My second visit was today at the new Beverly hospital in Gateshead with Aimee for polynucleotides. Aimee was welcoming and put me at ease immediately. She explained everything and made sure the whole process was painless !!
I’m looking forward to seeing the end results and have my second session booked in already Show less »
First time I saw Ness- who assessed me and advised me on a course of treatment to help with my skin pigmentation from years of sun damage. I am currently using a prescribed medical grade skin care and we are planning a skin peel to help correct years of damage.
I’ve known Ness for many years. She is very experienced in her field and is not afraid to say no to treatments not needed or advised which I respect. She has also done a fantastic job of growing her clinic with the addition of new clinicians and new premises.
My second visit was today at the new Beverly hospital in Gateshead with Aimee for polynucleotides. Aimee was welcoming and put me at ease immediately. She explained everything and made sure the whole process was painless !!
I’m looking forward to seeing the end results and have my second session booked in already Show less »
Helen Ross
Oracle Aesthetics Clinics Newcastle18 December 2025 20:08
I cannot recommend Dr Hadeel highly enough. From the moment I stepped into the clinic, I was struck by the professionalism, warmth, and meticulous attention to detail that defined the entire experience. Every stage of my treatments, from Botox and dermal fillers to HArmonyCa and under-eye polynucleotides.
The results have been nothing short of fantastic. My...
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I cannot recommend Dr Hadeel highly enough. From the moment I stepped into the clinic, I was struck by the professionalism, warmth, and meticulous attention to detail that defined the entire experience. Every stage of my treatments, from Botox and dermal fillers to HArmonyCa and under-eye polynucleotides.
The results have been nothing short of fantastic. My skin looks refreshed, natural, and rejuvenated- exactly the outcome I was hoping for. I wholeheartedly recommend Dr Handel for her professionalism, expertise, and the beautiful results she delivers. Show less »
The results have been nothing short of fantastic. My skin looks refreshed, natural, and rejuvenated- exactly the outcome I was hoping for. I wholeheartedly recommend Dr Handel for her professionalism, expertise, and the beautiful results she delivers. Show less »
Rita Bavington
HAVA Aesthetics18 December 2025 12:12
Recently had a course of polynucleotides and skinpen microneedling… I am blown away by my results. My skin looks brighter, healthier and just glowing even without makeup on. Kirsty explained everything in detail and eased my nerves straight away. She’s is so honest and down to earth I felt like I could ask her anything. I honestly couldn’t recommend the clin...
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Recently had a course of polynucleotides and skinpen microneedling… I am blown away by my results. My skin looks brighter, healthier and just glowing even without makeup on. Kirsty explained everything in detail and eased my nerves straight away. She’s is so honest and down to earth I felt like I could ask her anything. I honestly couldn’t recommend the clinic enough.
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Aimee Morgan
KSA Medical (The Aesthetics Room)18 December 2025 10:10
Botox 3 Areas (Alluzience), Dermal Filler & Polynucleotide (Eye)
couldn’t be happier with Josie and the results of my treatments. I was recommended Amethyst by a friend as previously I’ve always found I never quite got the results I wanted from my Botox (It would always wear off too quickly, too much movement) I had the Alluzience (3 areas) and the differen...
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Botox 3 Areas (Alluzience), Dermal Filler & Polynucleotide (Eye)
couldn’t be happier with Josie and the results of my treatments. I was recommended Amethyst by a friend as previously I’ve always found I never quite got the results I wanted from my Botox (It would always wear off too quickly, too much movement) I had the Alluzience (3 areas) and the difference within a few days were a game changer! additionally my nasolabial filler results were exactly how I wanted (natural, not overfilled, yet noticeably improved)
clear aftercare advice is always given, premium products used for every treatment & I feel the results I wanted to achieve were listened too. Thank you! Show less »
couldn’t be happier with Josie and the results of my treatments. I was recommended Amethyst by a friend as previously I’ve always found I never quite got the results I wanted from my Botox (It would always wear off too quickly, too much movement) I had the Alluzience (3 areas) and the difference within a few days were a game changer! additionally my nasolabial filler results were exactly how I wanted (natural, not overfilled, yet noticeably improved)
clear aftercare advice is always given, premium products used for every treatment & I feel the results I wanted to achieve were listened too. Thank you! Show less »
Pierce Heald
Amethyst Clinic17 December 2025 19:07
I’ve just completed a 4-day aesthetics course covering microneedling, tox, advanced tox, dermaplaning and polynucleotides, and I honestly couldn’t recommend it enough.
Beth was absolutely amazing from start to finish. Her knowledge is exceptional, and she explains everything so clearly and confidently, making even the more advanced treatments feel approacha...
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I’ve just completed a 4-day aesthetics course covering microneedling, tox, advanced tox, dermaplaning and polynucleotides, and I honestly couldn’t recommend it enough.
Beth was absolutely amazing from start to finish. Her knowledge is exceptional, and she explains everything so clearly and confidently, making even the more advanced treatments feel approachable and achievable. She is incredibly supportive, patient and kind, and creates such a welcoming learning environment where no question feels silly.
Beth’s passion for aesthetics really shines through in her teaching. I left the course feeling confident, inspired and genuinely excited to put my new skills into practice. If you’re considering training in aesthetics, learning from Beth is an absolute privilege — she is a true credit to the industry.♥️♥️♥️ Show less »
Beth was absolutely amazing from start to finish. Her knowledge is exceptional, and she explains everything so clearly and confidently, making even the more advanced treatments feel approachable and achievable. She is incredibly supportive, patient and kind, and creates such a welcoming learning environment where no question feels silly.
Beth’s passion for aesthetics really shines through in her teaching. I left the course feeling confident, inspired and genuinely excited to put my new skills into practice. If you’re considering training in aesthetics, learning from Beth is an absolute privilege — she is a true credit to the industry.♥️♥️♥️ Show less »
Andrea Kent
The Aesthetics Room Bromsgrove17 December 2025 15:03
I have been treated by Dr Coffey for 2 sessions of polynucleotides. I have had such a great experience and I have been really impressed with the results. Charlie made me feel comfortable and at ease throughout the treatment. She provided me with the clinical advice and expertise throughout, allowing me to fully understand the long term benefits of the treat...
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I have been treated by Dr Coffey for 2 sessions of polynucleotides. I have had such a great experience and I have been really impressed with the results. Charlie made me feel comfortable and at ease throughout the treatment. She provided me with the clinical advice and expertise throughout, allowing me to fully understand the long term benefits of the treatment and what to expect immediately after, and recovery time. Since the treatment my skin has felt hydrated and glowing. Great treatment by a great clinician. Many Thanks Hannah
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Hannah Lippa
Dr Coffey Skin17 December 2025 13:01
I had a Polynucleotide treatment and it’s absolutely fantastic! It’s the best thing for my face right now. The treatment has already transformed my under-eye area. Dr Susie was amazing; she explained the procedure and aftercare thoroughly. If anyone is worried about under-eye treatments, don’t be. They’re not bad at all. I’ll definitely be returning for top...
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I had a Polynucleotide treatment and it’s absolutely fantastic! It’s the best thing for my face right now. The treatment has already transformed my under-eye area. Dr Susie was amazing; she explained the procedure and aftercare thoroughly. If anyone is worried about under-eye treatments, don’t be. They’re not bad at all. I’ll definitely be returning for top-ups and other treatments.
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Jane Meadows
Dr Suzie Aesthetics17 December 2025 12:12
I had a Polynucleotide treatment and it’s absolutely fantastic! It’s the best thing for my face right now. The treatment has already transformed my under-eye area. Dr Susie was amazing; she explained the procedure and aftercare thoroughly. If anyone is worried about under-eye treatments, don’t be. They’re not bad at all. I’ll definitely be returning for top...
Show more »
I had a Polynucleotide treatment and it’s absolutely fantastic! It’s the best thing for my face right now. The treatment has already transformed my under-eye area. Dr Susie was amazing; she explained the procedure and aftercare thoroughly. If anyone is worried about under-eye treatments, don’t be. They’re not bad at all. I’ll definitely be returning for top-ups and other treatments.
Show less »
Jane Meadows
Dr Susie Aesthetics17 December 2025 12:12
I’ve been coming to Aaron for about 2 years for my treatments.
I have had a number of tweakments and the results from Botox, polynucleotides, fillers and chemical peels have all been fantastic!
I have fully put my trust in Aaron’s practice and won’t go anywhere else , highly recommended ! Thank you Aaron . BIG KISS
I have had a number of tweakments and the results from Botox, polynucleotides, fillers and chemical peels have all been fantastic!
I have fully put my trust in Aaron’s practice and won’t go anywhere else , highly recommended ! Thank you Aaron . BIG KISS
Emma Howland
Aaron Bishop Aesthetics17 December 2025 12:12
I’ve been to Claire for Botox, facials and polynucleotides and honestly couldn’t recommend her enough. Every appointment feels like a full-on experience - Claire is absolutely hilarious and so good at what she does. Thank you, Claire!!
Laura r
S10 Aesthetics & Beauty16 December 2025 19:07
Wow, where to begin! I have been coming to BU Aesthetics for years for all my beauty needs, from dermaplaning and WOW Fusion facials to Botox, polynucleotides, skin boosters, and medical-grade skincare. I genuinely wouldn’t trust anyone else with my face.
Caroline and her team have been absolutely brilliant - professional, knowledgeable, and supportive thro...
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Wow, where to begin! I have been coming to BU Aesthetics for years for all my beauty needs, from dermaplaning and WOW Fusion facials to Botox, polynucleotides, skin boosters, and medical-grade skincare. I genuinely wouldn’t trust anyone else with my face.
Caroline and her team have been absolutely brilliant - professional, knowledgeable, and supportive throughout my entire skin journey from the very beginning. There will never be enough thank-yous for helping me regain confidence in my own skin ✨
It has been such a pleasure following Caroline’s journey from room rental to her own luxurious clinic. Visiting the clinic is always a real treat—each room is stunning, calming, and incredibly relaxing.
The attention to detail in the clinic décor, treatments, and products is second to none… and those pink shoe coverings really top it off for me 🩷
If you’re considering any beauty or aesthetic treatments, do not hesitate to get in touch with Caroline and her team at BU Aesthetics. Exceptional quality, true professionalism, and a service I cannot thank them enough for 🫶 Show less »
Caroline and her team have been absolutely brilliant - professional, knowledgeable, and supportive throughout my entire skin journey from the very beginning. There will never be enough thank-yous for helping me regain confidence in my own skin ✨
It has been such a pleasure following Caroline’s journey from room rental to her own luxurious clinic. Visiting the clinic is always a real treat—each room is stunning, calming, and incredibly relaxing.
The attention to detail in the clinic décor, treatments, and products is second to none… and those pink shoe coverings really top it off for me 🩷
If you’re considering any beauty or aesthetic treatments, do not hesitate to get in touch with Caroline and her team at BU Aesthetics. Exceptional quality, true professionalism, and a service I cannot thank them enough for 🫶 Show less »
Emma Bendle
BU Aesthetics Wirral15 December 2025 18:06
I’ve been having Botox and Profhilo treatments at Norwich Aesthetics Clinic for the past four years and have recently started polynucleotides as well. The clinic is always exceptionally clean and I trust Dr Ryan completely, he consistently gives honest, expert advice tailored to what I’m looking to achieve. Every treatment has helped me look like the best ve...
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I’ve been having Botox and Profhilo treatments at Norwich Aesthetics Clinic for the past four years and have recently started polynucleotides as well. The clinic is always exceptionally clean and I trust Dr Ryan completely, he consistently gives honest, expert advice tailored to what I’m looking to achieve. Every treatment has helped me look like the best version of myself. I’m a very happy customer and will definitely continue returning.
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Sarah Quinn
Norwich Aesthetics Clinic14 December 2025 18:06
I regularly come in for my botox treatment to see Dr Mullan. He knows exactly what I am after and I also learn something new about beauty treatments from him every time! He talked me out of getting jaw filler, explaining exactly why it wouldn’t be a good idea with my skin type and facial structure.
My latest visit two days ago, we did the usual Bocouture and...
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I regularly come in for my botox treatment to see Dr Mullan. He knows exactly what I am after and I also learn something new about beauty treatments from him every time! He talked me out of getting jaw filler, explaining exactly why it wouldn’t be a good idea with my skin type and facial structure.
My latest visit two days ago, we did the usual Bocouture and the polynucleotides for my neck.
I have also previously had some Hydrafacials and Tempsure radiofrequency treatments with Joanna, who has the lightest touch and the most calming manner and is great at what she does!
I will keep coming back to Medicetics for sure. I’m just glad I found the place I can trust now! Show less »
My latest visit two days ago, we did the usual Bocouture and the polynucleotides for my neck.
I have also previously had some Hydrafacials and Tempsure radiofrequency treatments with Joanna, who has the lightest touch and the most calming manner and is great at what she does!
I will keep coming back to Medicetics for sure. I’m just glad I found the place I can trust now! Show less »
Irina R
Medicetics14 December 2025 13:01
FAQ
Is the treatment painful?
The injections may be slightly sensitive, but a numbing cream is usually applied to make the procedure comfortable.
How long do the results last?
The effects usually last 6 to 12 months, depending on your skin type and lifestyle.
Are there any risks?
The treatment is generally safe. Redness, swelling, or bruising usually disappears within a few days.
What does a treatment cost?
The costs vary per clinic, but are often between £260 and £520 per session.
Which clinics in the United Kingdom offer this treatment?
On Injectablesbooking, you can easily find clinics that offer this treatment. The platform provides an overview of recognised clinics and GMC-registered doctors. Compare clinics based on experience, prices, and reviews to make the best choice.
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4.8
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<1 km
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London, Pall Mall 120
<1 km
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- £ 180,00
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- £ 350,00
- Profhilo per 2 ml from
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London, Pall Mall 120
<1 km
- Botox zone from
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- Filler per ml from
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- Profhilo per 2 ml from
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