
A Rejuran treatment is an injectable procedure using polynucleotides designed to help improve overall skin quality. Rather than adding volume like traditional dermal fillers, this treatment focuses on supporting skin regeneration, cell renewal, and the skin's natural repair processes.
Rejuran is often considered for addressing signs of skin ageing, fine lines, certain types of acne scarring, enlarged pores, and uneven skin texture.
On this page, you can learn more about how a Rejuran treatment works, who it may be suitable for, what to expect during the recovery period, and when you might begin to see results.

A Rejuran treatment is an injectable procedure utilising polynucleotides (PN) aimed at supporting the natural repair processes within the skin.
Polynucleotides are DNA fragments used in aesthetic treatments to help support cell regeneration, tissue repair, and the production of collagen and elastin. This process may gradually improve the underlying structure of the skin.
Rejuran is commonly considered for:
Fine lines
Acne scars
Enlarged pores
Reduced skin elasticity
Dull skin
Skin ageing
Read more about Rejuran polynucleotides.
Polynucleotides are small DNA fragments used in regenerative aesthetic treatments.
They are introduced into the skin to support natural processes associated with:
Cell regeneration
Skin repair
Skin barrier support
Collagen production
Elastin production
This is why Rejuran is often regarded as a treatment that focuses on improving skin quality and supporting skin regeneration.
Rejuran aims to support natural skin renewal through biostimulation.
The polynucleotides help stimulate fibroblasts, which are the cells responsible for producing collagen and elastin. This process can help refine the skin's structure without adding artificial volume.
By encouraging skin regeneration, Rejuran may help with:
Improved skin quality
Enhanced hydration
Refined skin texture
Reduction of fine lines
Support for the skin barrier
Improvement in acne scarring
A more even skin texture
Rejuran is frequently used to address early signs of skin ageing and superficial fine lines.
By supporting tissue regeneration, Rejuran is sometimes recommended to help improve the appearance of certain types of acne scars.
As the skin's underlying structure improves, pores may appear more refined and less noticeable.
Individuals with dry, dull, or tired-looking skin often choose Rejuran to help restore a fresher appearance.
Rejuran can be carefully administered to target fine lines and delicate, thinning skin beneath the eyes.
A Rejuran treatment may be a suitable option for individuals who:
Want to improve their skin quality
Want to reduce fine lines
Have acne scarring concerns
Want to achieve a smoother, more even skin texture
Want to support their skin as it ages
Do not want to add volume, as with dermal fillers
A doctor will assess during a consultation whether the treatment is suitable for your skin condition and aesthetic goals.
Read more about Rejuran by age and Rejuran for men.
Consultation and skin assessment
Preparation and numbing cream
The Rejuran injections
Immediate aftercare advice
Gradual result development
Most patients find the procedure manageable, though experiences vary. Because the treatment involves multiple small injections across the treatment area, it can be slightly uncomfortable.
To help minimise discomfort, clinics typically apply a topical numbing cream prior to the procedure.
For the best possible outcome, a course of multiple treatments is usually recommended.
The exact treatment plan will depend on your:
Age
Skin condition
Treatment goals
Treatment area
Following the initial treatment course, maintenance treatments may be recommended.
For some people, two treatments may already provide visible improvements. For others, additional sessions may be needed.
During your consultation, a practitioner will create a personalised treatment plan based on your skin condition and aesthetic goals.
Because Rejuran works by stimulating natural skin regeneration, results take time to become visible.
Immediately following the treatment, you may experience mild redness, swelling, or small bumps at the injection sites. The final results will not be visible at this stage.
As the skin begins to heal, many patients report their skin feeling smoother and more hydrated.
During this period, the effects of increased collagen and elastin production typically become more apparent. The skin may look firmer, more even, and generally refreshed.
Rejuran is generally considered a safe treatment when performed by an experienced, qualified practitioner in a clinical environment. However, as with any injectable procedure, there are potential risks and side effects.
The treatment may not be suitable if you have:
Active skin infections
Inflammation in the treatment area
Certain medical conditions
Known hypersensitivity to any of the ingredients
Pregnancy or breastfeeding
During a consultation, a practitioner will assess whether the treatment is appropriate and safe for you.
Most side effects associated with Rejuran are mild and temporary. Common reactions at the injection sites include:
Redness
Swelling
Bruising
Tenderness
Small bumps at the injection sites
Read more about Rejuran side effects.
Following proper aftercare helps ensure a smooth recovery. Practitioners typically advise that for the first 24 to 48 hours, you should:
Avoid intense exercise
Avoid saunas and steam rooms
Limit direct sun exposure
Do not massage the injection sites
Only apply make-up according to your practitioner's advice
Rejuran is primarily used in areas where skin quality, texture, and elasticity are the main concerns.
The most frequently treated areas include:
Face
Cheeks
Under-eye area
Neck
Décolletage
It can be helpful to understand how Rejuran compares to other popular injectable treatments.
Feature | Rejuran vs Profhilo vs Skin Boosters |
|---|---|
Active ingredient | Rejuran: Polynucleotides Profhilo: Hyaluronic acid Skin Boosters: Usually hyaluronic acid |
Primary purpose | Rejuran: Skin regeneration and repair Profhilo: Skin hydration Skin Boosters: Skin hydration |
Skin repair focus | Rejuran: Strong focus Profhilo: Limited focus Skin Boosters: Limited focus |
Skin regeneration | Rejuran: Yes Profhilo: No Skin Boosters: Limited |
Volume effect | Rejuran: No Profhilo: No Skin Boosters: No |
Best suited for | Rejuran: Skin quality concerns and acne scarring Profhilo: Skin laxity and hydration Skin Boosters: Improving skin quality and hydration |
Are you considering a Rejuran treatment? It is important to find a reputable clinic and a qualified practitioner who understands your skin.
You can use Injectablesbooking to compare UK clinics, read patient reviews, and explore treatment options near you. Comparing clinics helps you get a better understanding of practitioner experience, treatment costs, and which clinic best aligns with your aesthetic goals.

While skinboosters primarily focus on deeply hydrating the skin using hyaluronic acid, Rejuran uses polynucleotides to actively support skin repair, cellular regeneration, and texture improvement.
Yes, Rejuran is often carefully administered under the eyes to help improve the appearance of fine lines, thinning skin, and overall skin quality in that delicate area.
This depends entirely on your skin condition. Many people consider Rejuran when they first begin to notice early signs of ageing, fine lines, or a general decline in skin texture and radiance.
Results can vary based on individual skin condition, age, and lifestyle. If you are not seeing the expected improvements, it may be related to the number of sessions completed or your specific treatment plan. Always discuss your progress with your practitioner.
Depending on the size of the area being treated, the actual injection process usually takes between 20 and 45 minutes.
It is normal to experience temporary redness, mild swelling, or small raised bumps at the injection sites. These typically subside within a few days.
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