
Rejuran Skinbooster is a common name for a Rejuran treatment with polynucleotides. Although Rejuran is often described as a skinbooster, it works differently from traditional hyaluronic acid skinboosters.
Traditional skinboosters mainly focus on hydration. Rejuran is more focused on supporting skin repair, collagen production and gradual improvement in skin texture.
This is why many people wonder whether Rejuran is really a skinbooster, or whether it belongs to a different category of regenerative injectable treatments. On this page, you can read what a Rejuran Skinbooster is, why the name is used and how it differs from other skinboosters.

Rejuran Skinbooster is a term used for a Rejuran treatment with polynucleotides. The treatment is often placed in the skinbooster category because it is aimed at improving skin quality, but it is not the same as a classic hyaluronic acid skinbooster.
Rejuran is an injectable treatment that uses polynucleotides, also known as PN. These ingredients are used in aesthetic medicine to support the skin’s natural repair processes and improve the appearance of skin texture, elasticity and overall skin quality.
Because Rejuran does not add volume in the same way as a filler, it is usually discussed as a skin-quality treatment rather than a volumising treatment.
Rejuran is a regenerative injectable treatment originally developed in South Korea. It contains polynucleotides, which are purified DNA fragments used in skin-quality treatments.
Rejuran may be considered for concerns such as:
Fine lines
Acne scarring
Enlarged pores
Reduced skin elasticity
Dull-looking skin
Uneven skin texture
It is often chosen by people who want to improve skin quality without adding facial volume.
Read more about Rejuran polynucleotides.
Rejuran is called a skinbooster because it can support improvement in skin quality without adding obvious volume.
Like traditional skinboosters, Rejuran is used to support:
A smoother-looking skin texture
Better overall skin quality
A fresher-looking complexion
Gradual improvement in visible signs of ageing
However, Rejuran is technically closer to a regenerative injectable than a classic hyaluronic acid skinbooster. The main difference is how it works in the skin.
Traditional skinboosters usually contain hyaluronic acid and are mainly used to attract and retain moisture in the skin. Rejuran uses polynucleotides, which are used to support processes involved in skin repair and collagen production.
Rejuran and traditional skinboosters are both used for skin-quality improvement, but their active ingredients and treatment goals are different.
Feature | Rejuran | Traditional skinbooster |
|---|---|---|
Main ingredient | Polynucleotides | Hyaluronic acid |
Main focus | Skin repair and regeneration | Hydration |
Mechanism | Supports regenerative skin processes | Helps bind water in the skin |
Collagen support | Stronger focus | Usually less direct |
Volume effect | Not designed as a filler | Not designed as a filler |
Rejuran may be more suitable when skin texture, acne scarring, fine lines or reduced elasticity are the main concerns. A hyaluronic acid skinbooster may be more suitable when hydration and skin glow are the main priorities.
Read the full comparison on Rejuran or skinboosters.
Rejuran works with polynucleotides that are injected into the skin using small intradermal injections. These ingredients are used in treatment protocols aimed at improving skin quality, texture and resilience over time.
Polynucleotides are part of the same wider family as PDRN, also known as polydeoxyribonucleotide. In aesthetic treatments, these ingredients are discussed for their role in regenerative skin improvement.
Fibroblasts are cells involved in producing collagen, elastin and supporting tissue within the skin. By supporting these processes, Rejuran may help the skin look gradually smoother, firmer and calmer.
Rejuran is often discussed for skin concerns such as acne scarring, fine lines, enlarged pores, reduced elasticity and uneven texture.
Read more about Rejuran polynucleotides.
Rejuran and Profhilo are often compared because both treatments are used to improve skin quality.
Profhilo contains hyaluronic acid and is best known for hydration and skin bio-remodelling. Rejuran contains polynucleotides and is more often discussed when skin repair, texture and regenerative skin improvement are the main focus.
Feature | Rejuran | Profhilo |
Main ingredient | Polynucleotides | Hyaluronic acid |
Main focus | Skin repair and texture | Hydration and bio-remodelling |
Regenerative focus | Stronger focus | Moderate focus |
Collagen support | Stronger focus | Moderate focus |
Volume effect | Not a filler | Not a filler |
The right option depends on your skin concerns, treatment history and suitability after consultation.
Read the full comparison on Rejuran or Profhilo.
Rejuran may be considered by people who want to improve skin quality without adding volume.
Possible concerns include:
Fine lines
Acne scarring
Enlarged pores
Reduced elasticity
Dull-looking skin
Uneven skin texture
Early visible signs of ageing
Suitability depends on your skin condition, medical history, expectations and the practitioner’s assessment during consultation.
Rejuran treatment usually starts with a consultation and skin assessment. If the treatment is suitable, the product is injected into the skin using small injections.
Many treatment plans involve more than one session, spaced over a number of weeks. The exact plan depends on the clinic, product used, treatment area and your skin goals.
Results usually develop gradually. Rejuran should not be viewed as an instant volumising treatment. It is more often used as part of a longer-term skin-quality plan.
Read more about the Rejuran treatment process.
Depending on the treatment plan, Rejuran may sometimes be combined with other aesthetic treatments, such as Profhilo, fillers, PRP or laser treatments.
Combination treatments should always be assessed by an appropriately trained practitioner. The timing, treatment order and suitability can vary per person.
Ask the clinic which practitioner will carry out the treatment, what experience they have with polynucleotide treatments and which aftercare advice applies to your skin.
Temporary reactions can occur after Rejuran injections. These may include redness, swelling, small injection bumps, tenderness or sensitivity in the treated area.
These effects are usually temporary, but recovery can vary depending on the treatment area, injection technique, skin sensitivity and aftercare.
Follow the aftercare advice given by your clinic. If you have unusual symptoms or concerns after treatment, contact the clinic for advice.
Read More:
Rejuran side effects
Rejuran recovery
If you are considering Rejuran, compare clinics carefully before booking.
Look at practitioner experience, consultation process, treatment information, reviews and whether the clinic clearly explains possible side effects, aftercare and expected results.
Injectablesbooking can help you compare clinics, practitioners, reviews and treatment information so you can make a more informed choice.

A Rejuran Skinbooster is a treatment with polynucleotides that is used to support skin repair, collagen production and improvement in skin quality.
Not exactly. Rejuran is often described as a skinbooster, but it works differently from traditional hyaluronic acid skinboosters.
The terms are often used in similar ways. In many cases, both refer to a Rejuran treatment aimed at improving skin quality with polynucleotides.
Not necessarily. A traditional skinbooster mainly focuses on hydration, while Rejuran is more focused on skin repair and texture. The better choice depends on your skin concerns.
No. Rejuran is not a filler. Fillers are used to add or restore volume, while Rejuran is used to support skin quality.
Rejuran uses polynucleotides, which are used in treatment protocols that support skin repair, collagen production and improvement in skin texture.
Results usually develop gradually over the weeks after treatment. The timeline can vary depending on your skin and treatment plan.
The duration of results varies per person and depends on skin condition, treatment area, lifestyle and the recommended treatment protocol.
Rejuran is used in aesthetic medicine, but no injectable treatment is risk-free. Temporary redness, swelling, tenderness or injection bumps can occur.
Polynucleotides are purified DNA fragments used in regenerative skin treatments to support skin-quality improvement.
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