Rejuran polynucleotides

Rejuran is an injectable product line based on polynucleotides, usually shortened to PN. Rejuran is the product name; polynucleotides are the DNA-derived material on which the core product is based.

That distinction matters. A clinic advertising ‘polynucleotides’, ‘PN’ or ‘salmon DNA’ is not automatically using Rejuran. If you are comparing treatments, ask for the exact product name and variant.

Rejuran is also not designed to build immediate structural volume in the same way as a traditional volumising dermal filler. What may visibly change depends on factors including the product used, treatment area, your skin, the reason for treatment and the treatment plan.

For a broader introduction to the brand and treatment, read our guide to Rejuran.

What are the polynucleotides in Rejuran?

Polynucleotides are chains made from nucleotides, the building blocks of DNA. For the core REJURAN product, the manufacturer lists PN, or polynucleotides, as the composition.

Rejuran and polynucleotides therefore do not mean exactly the same thing:

• Rejuran is a specific product line.

• PN stands for polynucleotides.

• Polynucleotides are an ingredient category, not a brand.

• Other injectable products can also contain polynucleotides.

Is Rejuran the same as polynucleotides?

No. Rejuran is a product line containing polynucleotides; polynucleotides are the broader ingredient category.

A ‘polynucleotide treatment’ therefore does not necessarily involve Rejuran. Two clinics could both offer PN injections while using different products.

Why is Rejuran called ‘salmon DNA’?

The PN technology behind Rejuran is derived from salmon-related DNA material. This is why the simpler term ‘salmon DNA’ is often used when discussing polynucleotide treatments.

However, PN, polynucleotides and the exact Rejuran product name are more useful when comparing treatments. The phrase ‘salmon DNA’ alone does not tell you which injectable product a clinic intends to use.

PN vs PDRN: what is the difference?

PN stands for polynucleotides. PDRN stands for polydeoxyribonucleotide. Both terms relate to DNA-derived materials, but they should not automatically be treated as interchangeable.

For Rejuran, the product-specific information matters most. PharmaResearch describes the core REJURAN product as containing PN.

Is Rejuran PN or PDRN?

PN is the more specific term for the core injectable Rejuran product in the manufacturer's current product information.

If a clinic uses terms such as PDRN, PN, polynucleotides or salmon DNA, ask which exact product is being injected. A general ingredient term is not enough to establish that the treatment is Rejuran.

What do polynucleotides do in the skin?

Injectable polynucleotides are studied for possible effects on characteristics of treated skin tissue. Biological discussions commonly involve fibroblasts, collagen, elastin and the extracellular matrix.

What are fibroblasts?

Fibroblasts are cells found in connective tissue. They play a role in producing and maintaining the extracellular matrix, the network surrounding cells that includes components such as collagen and elastin.

This biological mechanism does not mean that every Rejuran treatment produces a fixed amount of new collagen or a guaranteed visible improvement.

Does Rejuran stimulate collagen?

Collagen-related processes form part of the biological explanation for polynucleotide treatment. However, it is more accurate to say that PN treatments are being studied in relation to fibroblast activity, the extracellular matrix and collagen-related processes than to promise a particular increase in collagen.

Visible changes may differ according to factors such as your skin condition, treatment area, product variant, injection technique and treatment plan.

For a closer look at this specific question, read about Rejuran and collagen stimulation.

What does the product information say about Rejuran?

For the core REJURAN product, PharmaResearch lists PN, or polynucleotides, as its composition and describes an intended purpose relating to the temporary improvement of facial wrinkles.

That is more specific than broad marketing terms such as ‘skin rejuvenation’, ‘skin repair’ or ‘regeneration’. These phrases are commonly used when discussing polynucleotides, but they do not by themselves establish what effect an individual person will experience.

What does research into injectable polynucleotides show?

Clinical studies of injectable polynucleotides exist, but they do not all investigate the same product, treatment area, injection protocol or outcome.

For example, PN injections have been studied around the eye area and compared with other injectable products, with researchers measuring characteristics such as elasticity, hydration and skin texture.

Rejuran has also been investigated in defined facial areas. These studies can help explain why the product is being researched, but findings from one product, treatment protocol or anatomical area should not automatically be generalised to every Rejuran treatment.

Which Rejuran products are there?

The manufacturer's current international product information includes:

• REJURAN

• REJURAN i

• REJURAN s

• Rejuran HB plus

These products do not all have identical compositions or product specifications.

The brand name alone therefore does not tell you everything about the treatment. During consultation, ask which Rejuran variant will be used and why that particular product has been selected for the intended treatment area or goal.

Rejuran product variants explained

What can and can't Rejuran change?

Rejuran may be discussed when the treatment goal relates primarily to skin quality or certain characteristics of the skin. This does not mean it can correct every cause of lines, changes in skin texture or other cosmetic concerns.

Rejuran:

• does not create the same immediate structural volume as a traditional volumising dermal filler;

• does not relax facial muscles in the way botulinum toxin does;

• does not automatically correct significant volume loss, excess skin or pigmentation;

• cannot guarantee a particular result for wrinkles, scars or dark circles.

When might Rejuran polynucleotides be considered?

A practitioner may discuss polynucleotide treatment when the concern relates mainly to characteristics such as fine skin texture or certain superficial lines.

That does not mean Rejuran is automatically appropriate for you. A consultation should first consider what you would like to change and what is contributing to its appearance.

When might Rejuran be less relevant to the treatment goal?

If the main issue involves substantial volume loss, excess skin, muscle movement, pigmentation or an anatomical hollow, a treatment focused primarily on skin quality may not address the main cause.

The same visible concern can have more than one underlying factor. Assessment of the treatment indication therefore matters more than choosing Rejuran simply because of the product name.

If you mainly want to understand how visible outcomes can differ, see Rejuran before and after.

For more detail about consultation, preparation, injections and what happens during an appointment, read our guide to Rejuran treatment.

Reactions, risks and recovery

How can you check which polynucleotide product is being used?

A clinic offering ‘polynucleotides’ is not automatically offering Rejuran. The ingredient category also does not tell you which Rejuran variant would be used.

Before treatment, ask for the exact product name and variant.

What should you ask during a consultation?

Useful questions include:

• What exact product and variant will be injected?

• Why has this product been selected for my treatment goal?

• Who will perform the injections?

• What relevant training and experience do they have with this treatment and anatomical area?

• What limitations and risks are relevant?

• How are follow-up, aftercare and unexpected problems handled?

A brand name alone is not evidence that a treatment is suitable for you or that it will be performed well.

Look beyond the product name

When comparing practitioners, consider relevant professional qualifications or registration where applicable, clinical training, experience with injectable treatments, and experience with the particular anatomical area.

Professional registration or a job title alone does not prove extensive Rejuran experience. Also consider how clearly the practitioner explains the treatment plan, alternatives, realistic expectations, risks and aftercare.

For more detail, read how to choose a doctor for Rejuran.

How is Rejuran different from other injectable treatments?

Rejuran is often discussed alongside Profhilo, skinboosters and dermal fillers. These treatments should not be treated as interchangeable: their composition, treatment principles and treatment goals can differ.

This page should only provide the basic distinction. Use the dedicated comparisons if you are specifically deciding between treatment categories.

Compare Rejuran with other treatments

Traditional volumising fillers and Rejuran also have different primary treatment goals. If your decision is mainly between improving skin characteristics and adding structural volume, see Rejuran vs fillers.

Compare clinics offering Rejuran

If you want to explore treatment after learning more about Rejuran polynucleotides, you can compare clinics offering Rejuran and review the information available about their practitioners, location and treatment approach.

During consultation, ask which exact product will be used, why that product has been selected, what its limitations are and how aftercare is organised.

You can then decide whether you want to proceed with treatment. Choosing not to have treatment remains a valid option.

Frequently asked questions about Rejuran polynucleotides