Rejuran polynucleotides
Drs. Tom van Eijk
Rejuran polynucleotides are purified DNA fragments used in injectable skin-quality treatments. They are discussed in aesthetic medicine for their role in supporting skin texture, skin repair and overall skin quality.
Unlike dermal fillers, Rejuran is not designed to add obvious volume or change facial contours. Its focus is more on supporting the skin itself, including fine lines, texture, elasticity and delicate-looking skin.
Rejuran is the treatment or product line. Polynucleotides are the active ingredients used in the treatment. This is why the terms are often used together, even though they do not mean exactly the same thing.
Read more about the general Rejuran treatment if you want a broader introduction before looking at polynucleotides in detail.
What are polynucleotides?
Polynucleotides are chains of nucleotides, the building blocks of DNA. In aesthetic treatments, they are used because of their possible role in supporting skin repair, skin renewal and the extracellular matrix.
In purified form, polynucleotides are used in regenerative skin-quality treatments. They are often discussed in relation to:
skin repair;
skin texture;
collagen support;
elasticity;
skin-barrier support;
fine lines;
overall skin quality.
Polynucleotides are not designed to create filler-like volume. The aim is to support skin condition and skin quality rather than to reshape the face.
Term | Meaning |
Rejuran | Product line or treatment based on polynucleotides |
Polynucleotides | Active purified DNA fragments |
PN | Short for polynucleotides |
PDRN | A related DNA-derived ingredient |
Fibroblasts | Cells involved in collagen and elastin production |
What is the difference between Rejuran and polynucleotides?
Rejuran is the treatment or product name. Polynucleotides are the active ingredients used within the treatment.
A simple way to understand it is that Rejuran is the product line, while polynucleotides are the ingredient category.
Term | Meaning |
Rejuran | Treatment or product line |
Polynucleotides | Active ingredient |
PN | Short for polynucleotides |
PDRN | Related DNA-derived technology |
The confusion happens because some clinics talk about a Rejuran treatment, while others describe a polynucleotide treatment. In practice, both terms often refer to similar regenerative injectable skin-quality treatments, but the exact product and protocol can vary by clinic.
What is the difference between PN and PDRN?
PN and PDRN are both DNA-derived ingredients, but they differ in structure, fragment length and how they are described in aesthetic medicine.
Feature | PN | PDRN |
Full name | Polynucleotides | Polydeoxyribonucleotide |
Structure | Longer DNA chains | Shorter DNA fragments |
Common focus | Skin quality and regeneration support | Repair-focused applications |
Skin focus | Texture, elasticity and resilience | Support of repair processes |
Link with Rejuran | Often described as a core technology | Often compared with PN |
For most users, the key point is that Rejuran is known for using polynucleotides as a regenerative skin-quality technology. A practitioner can explain which product is being used and why it suits your skin.
What are Rejuran polynucleotides used for?
Rejuran polynucleotides are mainly considered when skin quality is the main concern.
They may be discussed for:
fine lines;
thin or delicate-looking skin;
reduced elasticity;
dull skin;
uneven texture;
superficial acne scarring;
skin ageing;
under-eye skin quality.
For more specific information, read about Rejuran for fine lines, Rejuran for acne scars and Rejuran under eyes.
Rejuran product variants
Within the Rejuran product line, different variants may be used for different skin concerns.
Product | Often discussed for |
Rejuran Healer | General skin quality |
Rejuran I | Delicate under-eye skin |
Rejuran S | Scars and texture concerns |
Rejuran HB | Hydration and skin quality |
The choice of product depends on the treatment area, skin concern, medical suitability and practitioner assessment.
Before and after photos of Rejuran
Rejuran polynucleotides and visible skin results
Before-and-after photos may help show the type of skin-quality changes people look for with Rejuran, such as smoother texture, softer-looking fine lines or improved overall skin appearance.
Photos should be viewed carefully. Results vary by person and depend on skin condition, treatment area, number of sessions, product choice, practitioner technique and aftercare.
Rejuran polynucleotides vs other injectables
Rejuran vs Profhilo
Feature | Rejuran | Profhilo |
Active ingredient | Polynucleotides | Hyaluronic acid |
Main goal | Skin repair and texture support | Hydration and elasticity |
Main focus | Skin quality and structure | Hydration and bioremodelling |
Type of treatment | Regenerative injectable | Bioremodelling injectable |
Read more on Rejuran vs Profhilo.
Polynucleotides vs fillers
Feature | Polynucleotides | Fillers |
Main goal | Skin quality | Volume and contour |
Action | Supports skin-quality processes | Adds volume or structure |
Result style | Gradual | Often more immediate |
Common use | Texture, fine lines and skin quality | Volume loss, folds and facial shaping |
Read more on Rejuran vs fillers.
Polynucleotides vs skin boosters
Many skin boosters use hyaluronic acid and focus mainly on hydration. Polynucleotides are more focused on regenerative skin-quality support and texture.
Read more on Rejuran vs skin boosters.
Are Rejuran polynucleotides safe?
Rejuran polynucleotides are used in aesthetic clinics, but they are not suitable for everyone. A consultation is needed to assess your skin, medical history, allergies, current medication and expectations.
Temporary side effects may include:
redness;
swelling;
small bumps;
bruising;
tenderness;
visible injection marks.
Treatment may be postponed or avoided during pregnancy or breastfeeding, with active skin infections, certain allergies or some medical conditions. Always follow the advice of your practitioner.
Read more about Rejuran side effects for a fuller explanation of possible risks.
Reviews of Rejuran treatments in the UK
Dr. Wen Sheng was excellent. He was very patient, the procedure was completely painless, and he took the time to give detailed recommendations on how the polynucleotides should be injected to best suit my facial structure. I really appreciated his professionalism and attention to detail. Show less »
Rupesh was very thorough during the consultation, looking at my facial structure, skin quality and overall balance. He is clearly very knowledgeable and medically trained but also so friendly and easy to talk to, which made me feel completely at ease, which is exactly what I wanted.
He used dermal fillers from the Revanesse range, which are known for causing less swelling and inflammation while still giving very natural looking results. In total he used 7 syringes to lift my cheeks and mid-face, define my jawline and chin, soften the lines from my nose to mouth and the lines around my mouth, and subtly enhance my lips. The result is fresh and lifted but still completely me.
He used both cannula and needle techniques and explained everything clearly, so I felt safe and confident throughout. The aftercare has been great too.
If you’re considering full face dermal fillers in London, especially on Harley Street, I would definitely recommend London Lip Clinic. Professional, natural results and a really positive experience. Show less »
The skin care and polynucleotides has made such a difference to my skin I feel amazing. Highly recommended so glad I found her!
I am always extremely happy with the results. Lee is so professional,so knowledgeable and so friendly and welcoming and so good at his job.
I highly highly recommend Lee and his lovely team.
Thank you for always making me feel so good. Show less »
Over the years I’ve had anti-wrinkle injections (Botox) and dermal fillers for my nose and cheeks, and the results have always been subtle, balanced and beautifully executed. I consistently look refreshed and well-rested, never “done.” In fact, I honestly look better than I did 10 years ago, and that is entirely thanks to Jane’s skill and expertise.
She takes time to assess your face holistically, explains everything clearly, and never over-treats. What really sets her apart is her refined Korean approach to aesthetics; focusing on skin quality, balance, and natural regeneration rather than obvious volume. The results are elegant, harmonious, and incredibly natural.
If you’re considering any injectables, including Botox, dermal fillers, polynucleotides, or Sculptra, I wouldn’t go anywhere else. Dr Moon Clinic is exceptional and I highly recommend her for subtle, sophisticated results! Show less »
Compare Rejuran clinics
If you want to know whether Rejuran polynucleotides suit your skin goals, compare clinics and practitioners carefully. Look beyond price and check experience, consultation quality, treatment explanation and aftercare.
Useful pages to read next include:
This gives you a clearer view of the treatment, possible results and available UK clinics.
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Frequently asked questions about Rejuran polynucleotides
What are polynucleotides?
Polynucleotides are chains of nucleotides, the building blocks of DNA. In aesthetic treatments, they are used to support skin quality, texture and regenerative skin processes.
Why does Rejuran use polynucleotides?
Rejuran uses polynucleotides because they are associated with skin repair support, collagen-related processes and improvement in overall skin quality.
What does PN mean in Rejuran?
PN stands for polynucleotides. These are the active ingredients used in Rejuran treatments.
What is the difference between PN and PDRN?
PN usually refers to longer DNA chains, while PDRN refers to shorter DNA fragments. Both are discussed in regenerative aesthetic treatments.
Are Rejuran polynucleotides the same as fillers?
No. Fillers are mainly used for volume and contour. Polynucleotides are mainly used for skin quality, texture and gradual skin support.
Are Rejuran polynucleotides the same as Profhilo?
No. Rejuran uses polynucleotides, while Profhilo is based on hyaluronic acid. Their treatment goals can overlap, but the technologies are different.
Are Rejuran polynucleotides a skin booster?
Rejuran is sometimes described as a skin-quality injectable, but it is different from classic hyaluronic acid skin boosters. It is more focused on skin repair and texture support.
Can polynucleotides stimulate collagen?
Polynucleotides are often linked with fibroblast support and processes involved in collagen formation. Results vary by person and treatment plan.
Are Rejuran polynucleotides derived from salmon DNA?
Many polynucleotide products are based on purified DNA fragments from salmonid sources. The final product contains purified ingredients prepared for medical aesthetic use.
Is Rejuran I better than fillers?
Not necessarily. Rejuran I is mainly used for skin quality in delicate areas such as around the eyes. Fillers are more often used for volume loss or contour.
Who are Rejuran polynucleotides suitable for?
They may be suitable for people who want to improve skin quality, texture, elasticity or fine lines. A practitioner should assess whether the treatment is appropriate.
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