Rejuran not working

Tom van Eijk
The article is written by: Drs. Tom van Eijk

Rejuran not working simply means that Rejuran does not always look visibly effective straight away. Results are usually subtle and build gradually, because Rejuran with polynucleotides is used to support skin quality and the skin’s natural repair processes.

Improvements in skin texture, hydration and elasticity may only become more noticeable after several sessions. On this page, you can read why results may feel disappointing, which factors can influence the outcome and when to contact your clinic or practitioner for advice.

Want to understand how the treatment normally works first? Read more about the Rejuran treatment.

Rejuran not working

Why does Rejuran sometimes seem not to work?

Rejuran can take longer to show visible change than some people expect. This is because it is not designed to add instant volume. It is mainly used to support gradual improvement in skin quality.

Possible reasons include:

Too few sessions
Most people need more than one session. Expecting a major change after a single treatment may lead to disappointment.

Judging the result too early
The skin needs time to respond. Subtle improvement may become clearer after a few weeks.

Expectations that do not match the treatment
Rejuran is not a filler. It does not give immediate volume, but focuses more on skin texture, hydration and fine lines.

Skin condition and treatment indication
For deep lines, marked skin laxity, hollows under the eyes or clear volume loss, Rejuran may give a less noticeable result.

When should you normally see results from Rejuran?

Results vary from person to person. Skin type, age, skin condition, lifestyle and the number of sessions can all affect the outcome.

Moment

What you may notice

Immediately after treatment

Mild redness, swelling or small bumps

After a few days

The skin usually settles

After 2 to 4 weeks

Subtle improvement in skin texture and hydration

After several sessions

A clearer effect on fine lines and skin quality

For realistic expectations, also view the page about Rejuran before and after results.

Is one Rejuran treatment enough?

For most people, one Rejuran treatment is not enough to see a clear result. The effect usually builds after a course of several sessions.

The number of treatments needed depends on your skin, the area treated and the goal of the treatment. Discuss this during a consultation with a doctor, nurse prescriber or experienced aesthetic practitioner.

Rejuran does not add volume like fillers

Rejuran is mainly used to improve skin quality. It may help with hydration, fine lines and uneven skin texture, but it does not give immediate volume in the way fillers can.

If your main concern is deep folds, hollow areas or volume loss, a filler or combination treatment may be more suitable. Not sure whether you need skin improvement or volume restoration? Read the comparison between Rejuran and fillers.

Which concerns may respond less well to Rejuran?

Rejuran is not always the best option for every skin concern. Results may be less obvious for:

  • Deep wrinkles or significant skin laxity

  • Hollows under the eyes

  • Clear volume loss

  • Active acne

  • Some scars, depending on the scar type and product variant used

A careful assessment is especially important around the eye area. Read more about Rejuran under the eyes for fine lines, dark circles and thin skin.

Rejuran not working

When should you contact the clinic?

Contact your clinic, doctor or practitioner if you are unsure about healing, the result or possible side effects.

You should ask for advice if you notice:

  • Unusual redness, pain or swelling

  • Little or no visible change after a full course

  • Questions about follow-up sessions

  • Doubts about whether Rejuran is the right treatment for your concern

What can you do if you are not satisfied?

If you are not happy with the result, book a follow-up consultation first. A practitioner can assess whether your skin has had enough time to respond and whether further sessions may be useful.

It may help to:

  • Compare before and after photos

  • Discuss whether your expectations were realistic

  • Ask whether another treatment may be more suitable

  • Have your skin reassessed by an experienced clinic or practitioner

  • You can also read what to look for when choosing a Rejuran practitioner.

Rejuran compared with other treatments

Treatment

Main effect

Sessions, recovery and suitability

Rejuran

Skin quality and hydration

Usually 2–4 sessions. Recovery is usually short. Often suitable for subtle skin improvement and fine lines.

Profhilo

Hydration and elasticity

Usually 1–2 sessions. Recovery is usually short. Often suitable for dry skin, face and neck.

Skin boosters

Hydration and skin texture

Usually 2–3 sessions. Recovery is usually short. Often suitable for dry or dull skin.

Fillers

Volume restoration

Usually 1–2 sessions. Recovery of a few days is possible. Often suitable for hollows, folds and volume loss.

A practitioner can assess which treatment may suit your skin, expectations and desired result during a consultation.

Before and after photos of Rejuran

Rejuran picture of SkinSurgery Clinics Bergschenhoek (before)
Rejuran picture of SkinSurgery Clinics Bergschenhoek (after)
These pictures are from SkinSurgery Clinics Bergschenhoek
Rejuran picture of Oran Aesthetics (before)
Rejuran picture of Oran Aesthetics (after)
These pictures are from Oran Aesthetics

Compare Rejuran clinics and practitioners

If you want a second opinion or would like to compare another clinic, look at experience with Rejuran, clear explanation, realistic expectations, patient reviews and transparent treatment information.

Use the search function to compare Rejuran clinics or practitioners in the United Kingdom.

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Frequently asked questions about Rejuran not working

Why is Rejuran not working for me?

Is it normal to see no difference after one Rejuran treatment?

How long should I wait for Rejuran results?

Can Rejuran be injected incorrectly?

When is another treatment better than Rejuran?

Should I have Rejuran again if I see no resul

Is Rejuran S suitable for scars?

Why can Rejuran feel painful?

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