Rejuran for Fine Lines

Q: Does Rejuran remove wrinkles?

No. Rejuran does not remove wrinkles completely and does not fill lines like dermal fillers. It focuses on skin quality, so some superficial lines may look softer over time.

Q: Which fine lines may improve with Rejuran?

Rejuran is usually discussed for superficial fine lines linked to thin, crepey or less elastic skin. Deep folds or strong movement-related wrinkles may need another treatment.

Q: When is Rejuran not suitable for fine lines?

Rejuran may be less suitable when lines are mainly caused by muscle movement, deep folds, clear volume loss or significant skin laxity. A practitioner can advise on alternatives.

Q: Is Rejuran I suitable under the eyes?

Rejuran I is often discussed for the delicate under-eye area. Whether it is suitable depends on your skin, symptoms and medical history, and should be assessed during consultation.

Q: Is Rejuran S used for fine lines?

Rejuran S is more often discussed for scars or uneven texture. For fine lines, the practitioner will usually focus on the area, skin quality and treatment goal.

Q: Is Rejuran better than Botox for fine lines?

Not always. Botox is often more suitable for lines caused by muscle movement, such as frown lines or crow’s feet. Rejuran may be more suitable for thin or crepey skin texture.

Q: Is Rejuran better than fillers for fine lines?

It depends on the cause. Fillers are used for volume support or deeper folds. Rejuran does not add volume, but focuses on skin quality and texture.

Q: Can Rejuran be combined with Botox or fillers?

Sometimes, yes. Rejuran may be combined with Botox, fillers, Profhilo or skinboosters when different causes are involved. A combined plan is not always needed.

Q: Can Rejuran help crow’s feet?

Crow’s feet are often caused by muscle movement, so Botox may be more targeted. If there is also thin or crepey skin around the eyes, Rejuran may be discussed as a skin-quality treatment.

8 July 2026

The contents of this article is medically checked by:
Drs. Tom van Eijk

Rejuran for fine lines is often considered by people who want to improve thin, crepey or less even-looking skin. It is not a filler that adds volume, and it is not a muscle-relaxing treatment like Botox.

Rejuran is a polynucleotide injectable treatment that is usually discussed for skin quality, texture, elasticity and gradual skin repair. Whether it is suitable depends on why the fine lines are visible.

Fine lines may be linked to thin skin, early collagen loss, dryness, sun damage, facial movement or volume loss. Rejuran is usually more relevant when the skin itself looks fragile, crepey or less elastic. If the lines are deeper, caused by strong facial movement or linked to volume loss, Botox, fillers, Profhilo, skinboosters or a combined plan may be more suitable.

On this page, you can learn when Rejuran may be considered for fine lines, when another treatment may be better, what recovery can involve and how to compare clinics in the UK.

Does Rejuran work for fine lines?

Rejuran may help fine lines look softer when they are linked to thin skin, reduced elasticity, early collagen loss or a crepey skin texture. Its main focus is skin quality rather than volume correction.

This distinction matters. Rejuran does not fill lines like dermal fillers and does not relax facial muscles like Botox. A qualified practitioner should assess whether the lines are mainly caused by skin quality, movement, dryness or volume loss.

If the concern is mainly frown lines, crow’s feet from repeated movement, deep folds or loss of facial volume, another treatment may be more appropriate.

What does Rejuran do for fine lines?

Rejuran is usually discussed as a skin-quality treatment. For fine lines, it may be relevant when the skin looks thinner, less elastic or slightly crepey.

It does not create an instant plumping effect like fillers. It also does not stop muscle movement like Botox. The aim is a gradual improvement in skin condition, which may make superficial lines look softer over time.

Which fine lines may suit Rejuran best?

Concern	Why Rejuran may be discussed
Fine lines from thin skin	Rejuran may be considered when the skin looks fragile, thin or less resilient.
Crepey skin under the eyes	The under-eye area is thin and delicate. Rejuran I may be discussed for fine lines and crepey texture in this area.
Early cheek lines	Fine cheek lines may be linked to collagen loss, sun damage or reduced elasticity.
Fine lines around the mouth	Rejuran may suit superficial texture concerns, but deeper folds often need a different approach.
Dull or dry-looking skin with fine lines	Skinboosters or Profhilo may sometimes be more suitable if hydration is the main issue.
Fine lines with reduced elasticity	Rejuran may be discussed when the skin looks less firm or less springy.

When may Rejuran be less suitable?

Rejuran is not always the best option for fine lines. A practitioner may recommend another treatment when the cause of the lines is different.

Situation	Treatment that may be more suitable
Dynamic wrinkles from facial movement	Botox may be more targeted for frown lines or crow’s feet caused by muscle activity.
Deep folds or volume loss	Dermal fillers may be discussed when volume support or lifting is needed.
Mainly dry or dull skin	Skinboosters or Profhilo may be considered if hydration is the main concern.
Significant skin laxity	Rejuran alone is unlikely to be enough. A broader treatment plan may be needed.
Unrealistic expectations	Rejuran does not remove wrinkles completely or give an instant filler-like result.

Rejuran, Botox, fillers or skinboosters for fine lines?

Different treatments suit different causes of fine lines. The best option depends on whether the line is caused by movement, skin quality, dryness or volume loss.

Treatment	Mainly used for	When it may fit fine lines
Rejuran	Skin quality, texture and elasticity	Fine lines linked to thin, crepey or ageing skin
Botox	Muscle-related wrinkles	Frown lines, forehead lines or crow’s feet caused by movement
Fillers	Volume support and deeper folds	Lines caused by volume loss or structural support changes
Skinboosters	Hydration and glow	Dryness lines or dull skin where hydration is the main concern
Profhilo	Hydration and skin firmness	Wider skin-quality concerns with laxity or dehydration

Rejuran can sometimes be combined with other treatments, but this is not always needed. A good clinic should explain why a treatment is recommended and what result is realistic.

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Does Rejuran remove wrinkles?

No. Rejuran does not fully remove wrinkles and does not directly fill them. It is usually discussed for skin quality, texture and elasticity.

Fine, superficial lines may look softer if the surrounding skin improves. However, deeper wrinkles, clear folds or lines caused mainly by facial movement usually need a different approach, such as Botox, fillers or a combined treatment plan.

How does a Rejuran treatment for fine lines work?

1 Consultation and skin assessment
2 Discussion of your goals and expectations
3 Assessment of whether Rejuran, Botox, fillers, Profhilo or skinboosters fit best
4 Treatment plan, including area, number of sessions and realistic outcome
5 Small injections into or just under the skin
6 Short recovery period with possible redness, swelling, bumps or bruising
7 Review of results after the skin has settled
8 Maintenance discussion if suitable

How many Rejuran treatments are needed for fine lines?

For fine lines, clinics often discuss a course of several sessions rather than one single treatment. The exact number depends on skin condition, treatment area, age, skin thickness, lifestyle and the result you want.

Maintenance may be discussed later, but this should be based on how your skin responds. More sessions do not automatically mean a better result. A careful plan is more important than doing as many treatments as possible.

When can you see results from Rejuran for fine lines?

Rejuran is not usually judged in the same way as fillers. Fillers can give an immediate volume effect, while Rejuran is usually assessed gradually.

Timing	What you may notice
Directly after treatment	Redness, small bumps or swelling may be visible
First few days	The skin settles and bumps usually reduce
After several weeks	Skin quality may start to look smoother or calmer
After a course of treatment	Fine lines may look softer if skin quality improves
Maintenance phase	The result depends on your skin, lifestyle and treatment plan

Results vary. Age, skin condition, sun exposure, smoking, skincare and the number of sessions can all influence the outcome.

Recovery and side effects

After Rejuran, temporary side effects can include redness, swelling, small bumps, bruising, tenderness or a mild burning feeling. These usually settle, but recovery time varies by person, treatment area and injection technique.

The under-eye area can react more visibly because the skin is thinner. Small bumps may be noticeable shortly after treatment, so avoid booking treatment immediately before an important event.

Aftercare advice may include avoiding rubbing or massaging the area, intense exercise, sauna, heat, alcohol and make-up over visible injection points for the period advised by your clinic. Daily SPF is also usually recommended.

Contact your clinic if you notice worsening pain, heat, pus, fever, increasing redness, significant swelling or symptoms that worry you.

Treatment may be delayed if you have an active skin infection, inflammation in the treatment area, are pregnant or breastfeeding, or have a medical condition that needs review first. If you use blood thinners or have a condition affecting healing or immunity, discuss this before treatment.

Read more: Rejuran recovery and Rejuran side effects

Rejuran I, Rejuran S and fine lines

Different Rejuran variants may be discussed depending on the treatment area and concern.

Rejuran I is often discussed for the eye area, where the skin is thin and delicate. It may be considered for fine lines or crepey texture under the eyes after assessment.

Rejuran S is more often discussed for scars or uneven skin texture. If scarring is the main concern, a scar-focused Rejuran page may be more relevant.

For fine lines, the key factor is not only the product variant. The practitioner should assess your skin condition, the cause of the lines, the area being treated and the safest technique.

Is Rejuran suitable for your fine lines?

Rejuran may be suitable if your fine lines are mainly linked to thin skin, crepey texture, early collagen loss, reduced elasticity or overall skin quality.

It may be less suitable if the lines are mainly caused by strong facial movement, deep folds, clear volume loss or significant skin laxity. In those cases, Botox, fillers, Profhilo, skinboosters or another treatment plan may be more appropriate.

When comparing clinics, look for a clear consultation, careful explanation of risks, realistic expectations, aftercare advice and experience with skin-quality treatments. The best clinic should be able to explain when Rejuran is suitable and when it is not.