Rejuran Recovery & Aftercare
Drs. Tom van Eijk
Rejuran recovery refers to the period after treatment when the skin heals from the injections, and temporary reactions such as redness, mild swelling, injection marks, and small papules begin to subside.
Rejuran is a polynucleotide treatment designed to support skin regeneration, collagen production, and overall skin quality. On this page, you will find out exactly what to expect during the recovery process, which reactions are typical, and when it is advisable to contact your practitioner.
If you would like to know more about the procedure itself, read our full guide on how a Rejuran treatment works.
What to expect immediately after Rejuran
Directly after a Rejuran treatment, you may notice temporary injection-related reactions. This is a normal response from the skin.
Common reactions include:
Redness
Mild swelling
Small bumps or papules
Visible injection marks
Sensitivity
Mild bruising
A warm or tight sensation
These reactions generally do not indicate a problem. The skin simply needs time to recover from the injections and the temporary inflammatory response they cause.
Why can Rejuran be uncomfortable?
Rejuran is administered via tiny injections into the skin. Areas with thinner skin, such as under the eyes, may feel more sensitive. The injection points may also remain slightly tender during the first few days of recovery.
Any discomfort should gradually subside. Contact your practitioner if the pain increases or is accompanied by severe redness or swelling.
How long does Rejuran recovery take?
Recovery after Rejuran typically takes a few days. Redness, mild swelling, and small papules often subside within 24 to 72 hours. Bruising may remain visible a little longer. The improvement in skin quality will then develop gradually in the weeks following the treatment.
Time after treatment | What to expect |
|---|---|
Immediately | Redness, papules, mild swelling, and injection marks |
First 24 hours | Sensitive skin and visible injection reactions |
Days 2–3 | Swelling and papules usually begin to subside |
Days 4–7 | The skin typically looks much calmer |
Weeks 2–4 | Initial improvements in skin quality may become visible |
Recovery varies per person. Factors such as skin type, treated area, injection technique, and individual sensitivity can all influence the healing timeline.
First 24 hours: Redness, swelling, and small papules are usually most apparent. Touch the treated area as little as possible.
Days 2 to 3: Swelling and injection bumps often decrease. Any bruising may still be visible, especially around the eyes.
Days 4 to 7: For most people, the visible injection reactions will have faded. The skin feels calmer and looks more even.
Weeks 2 to 4: During this phase, the focus shifts from recovery to skin improvement. The skin may start to feel smoother, firmer, and more hydrated.
For more details on how long results can last, visit our page on Rejuran results and longevity.
Is there downtime with Rejuran?
Yes, but the downtime associated with Rejuran is usually minimal.
Many people can resume their daily activities almost immediately. However, because redness, papules, swelling, or bruising may be temporarily visible, some patients prefer not to schedule the treatment right before an important meeting, event, or photoshoot.
Most visible reactions fade within a few days.
When do redness, swelling, and papules disappear?
Redness and mild swelling generally fade within a few days. The small bumps at the injection sites usually disappear within 24 to 72 hours. Bruises may take a little longer to fully clear.
Reaction | Usually normal for | Contact a practitioner if |
|---|---|---|
Redness | A few hours to days | Redness increases significantly |
Mild swelling | 1 to 3 days | Swelling continues to worsen |
Papules (bumps) | 1 to 3 days | Bumps remain hard or painful |
Bruising | A few days or longer | The bruise rapidly expands |
Sensitivity | Temporarily | Pain continues to increase |
If you would like to read more about possible complications, please view our page on Rejuran side effects.
Are small bumps normal after Rejuran?
Yes. Small bumps or papules after Rejuran are a standard reaction to the injections.
They appear because the product is placed superficially into the skin. Over time, the polynucleotides disperse into the surrounding tissue, and the bumps disappear on their own. Around the eyes, these papules may occasionally be visible for slightly longer because the skin in this area is much thinner.
What if the bumps do not disappear?
Contact your clinic if the bumps:
Become painful
Remain red
Feel hard to the touch
Last significantly longer than expected
An aesthetic practitioner or doctor can assess whether your recovery is progressing normally.
Normal reactions vs. When to seek advice
During your recovery, it is helpful to know the difference between standard injection reactions and symptoms that may require a medical check.
Normal after Rejuran | Seek advice if you experience |
|---|---|
Mild redness | Increasing, spreading redness |
Mild swelling | Severe or asymmetrical swelling |
Small bruises | Increasing or severe pain |
Temporary sensitivity | Signs of infection (e.g. heat, pus) |
Small papules | Hard bumps that do not resolve |
If in doubt, always contact the clinic where you were treated for professional guidance.
Rejuran aftercare: What to do and what to avoid
Following the correct aftercare can support a smooth and safe recovery process.
Aftercare checklist:
Avoid intense exercise immediately after the treatment.
Avoid saunas, steam rooms, and excessively hot showers.
Protect your skin with a high SPF.
Use gentle, unfragranced skincare.
Avoid retinol, chemical peels, and strong active acids.
Touch the treated area as little as possible.
Do not apply makeup over open injection points.
Always follow the specific aftercare protocol provided by your practitioner.
Exercise after Rejuran Exercise increases blood flow, which can temporarily worsen redness and swelling. It is advisable to wait until the skin has settled before resuming strenuous workouts.
Makeup after Rejuran Avoid using makeup as long as there are visible injection points or skin irritation. Once the skin is closed and calm, makeup can usually be applied again.
Saunas, heat, and sun exposure Heat can exacerbate swelling and redness. Avoid saunas, sunbeds, and prolonged exposure to strong sunlight during the initial recovery phase.
Alcohol after Rejuran Alcohol can affect blood circulation and may increase the likelihood of bruising or swelling for some people. It is best to limit alcohol consumption around the time of your treatment.
How can you support your recovery?
You can support your recovery by keeping the skin calm, using adequate sun protection, temporarily avoiding aggressive skincare products, and strictly following your practitioner’s instructions.
The following can also help:
Staying well-hydrated
Applying daily SPF
Using a mild cleanser
Getting plenty of rest
Please note that while these steps support the healing process, they do not guarantee faster results. Rejuran works gradually, as the treatment focuses on cellular skin repair and collagen stimulation over time.
Can I work after a Rejuran treatment?
In most cases, you can return to work and resume your daily activities straight after a Rejuran treatment.
However, keep in mind that temporary redness, papules, or mild swelling may be visible. If you have an important meeting, presentation, or social event, you may want to schedule your treatment a few days in advance.
Is recovery under the eyes different?
Yes. The skin under the eyes is thinner and more delicate than many other parts of the face.
Because of this, swelling, bruising, and papules may be slightly more noticeable or take a little longer to clear than in other treated areas.
You can find more information about treating this specific area on our Rejuran under eyes page.
When will I see results after Rejuran?
The results of Rejuran are usually not immediately visible. The skin must first recover from the injections. Following this, skin quality can gradually improve over the weeks following the procedure.
Rejuran is not a dermal filler designed to add instant volume. Instead, it is a regenerative treatment aimed at stimulating collagen production and improving overall skin health.
Want to know more? Read our detailed guide on Rejuran and skin quality.
Rejuran recovery vs. Profhilo recovery
Both Rejuran and Profhilo have relatively short recovery periods, but the treatments work via different mechanisms.
Feature | Rejuran | Profhilo |
|---|---|---|
Active ingredient | Polynucleotides | Hyaluronic acid |
Papules possible? | Yes | Yes |
Swelling | Mild and temporary | Mild and temporary |
Downtime | Minimal | Minimal |
Primary result | Skin regeneration | Deep hydration |
Focus | Cellular repair | Skin quality & moisture |
If you want a more detailed comparison, visit our Rejuran vs Profhilo page.
Is aftercare included?
Comprehensive aftercare should always be part of a professional Rejuran treatment plan.
A reputable clinic will provide clear instructions regarding your recovery, what reactions to expect, and when you should contact them. This ensures a safe treatment journey and helps manage realistic expectations.
For more information on treatment pricing, visit our Rejuran costs page.
Compare Rejuran clinics
A smooth recovery starts with a carefully performed treatment, clear aftercare instructions, and a clinic that is easily accessible if you have questions afterwards.
When comparing Rejuran clinics, look beyond the price and consider:
Medical oversight and safety protocols
The clinic's aftercare policies
Accessibility and follow-up support
Patient reviews
Read experiences from other patients on our Rejuran reviews page, or book a no-obligation consultation with a qualified aesthetic practitioner near you.
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Frequently asked questions about Rejuran recovery
How long does Rejuran recovery take?
Recovery generally takes a few days. Redness, mild swelling, and small papules usually subside within 24 to 72 hours.
Is there downtime after Rejuran?
Yes, but it is minimal. Most people can resume normal daily activities straight away, though visible injection marks may be present for a few days.
Are small bumps normal after treatment?
Yes. Small papules or bumps are a standard reaction to the superficial injections and usually fade within a few days.
When will the redness disappear?
Redness and mild swelling typically fade within a few hours to a few days.
Does the treatment hurt?
Rejuran involves tiny injections, so some areas may feel temporarily tender or uncomfortable, particularly where the skin is thin.
What is the most important aftercare advice?
Use SPF, avoid excessive heat and strenuous exercise, keep the skin clean, and strictly follow your practitioner's aftercare protocol.
Can I go to work after Rejuran?
Usually, yes. However, bear in mind that temporary redness or small bumps may be visible on your face.
Can I exercise after the procedure?
It is best to wait until your skin has settled, as exercise increases blood flow and can temporarily worsen swelling and redness.
When can I wear makeup again?
Avoid wearing makeup whilst the injection points are still open or irritated. Once the skin is calm, makeup can usually be reapplied.
Is recovery different under the eyes?
Yes. Because the skin under the eyes is thinner, swelling, papules, and bruising may be slightly more noticeable in this area.
When will I notice skin improvements?
Initial improvements in skin quality generally become visible in the weeks following the treatment, once the skin has fully recovered and collagen production is stimulated.
When should I contact my clinic?
Contact your practitioner if you experience increasing redness, severe swelling, worsening pain, signs of infection, or hard lumps that do not resolve.
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