Hyaluronic acid filler treatment

There are various brands of hyaluronic acid fillers, including both well-known and lesser-known names. On this page, you’ll find an overview of the most recognised hyaluronic acid filler brands. These brands have all been around for many years, are used worldwide, and have published multiple scientific studies. These are considered top-tier (A-brand) fillers.

Hyaluronic acid filler treatment

What is a Hyaluronic Acid Filler?

A hyaluronic acid filler is an injectable, clear gel used to enhance the shape, structure, and volume of the skin. These fillers are made from hyaluronic acid, a substance naturally found in the body that helps to hydrate and strengthen the skin. By injecting small amounts of hyaluronic acid filler, wrinkles can be smoothed, facial contours improved, and volume restored in areas such as the cheeks, lips, and jawline. Modern hyaluronic acid fillers provide natural and safe results and are used by doctors worldwide to achieve a fresh, youthful appearance.

Hyaluronic Acid Fillers

Around 20 years ago, permanent fillers were used, but these are now widely banned. Around the year 2000, temporary fillers were introduced, made from hyaluronic acid.

Hyaluronic acid is a substance naturally present in the body, including in joints and the skin. With a hyaluronic acid filler, a cosmetic doctor can smooth out wrinkles, correct unevenness, or restore sagging skin. As we age, skin volume decreases, but hyaluronic acid fillers can help restore it. They are also commonly used to enhance facial contours. Areas such as the lips, cheekbones, fine lines, and dark circles under the eyes can be subtly improved or rejuvenated.

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What are Hyaluronic Acid Fillers?

Hyaluronic acid is a substance naturally found in the body. Its unique ability is to bind water—1 gram of hyaluronic acid can hold up to 6 litres of water. Since the skin is made up of around 80% water, you can imagine how a wrinkle can be smoothed by injecting a small amount of hyaluronic acid into the right layer of skin beneath it.

Are All Fillers the Same?

There are many types of hyaluronic acid fillers. Generally, they range from very soft to slightly firmer. A very soft filler, for example, is suitable for the lips, while a firmer filler is designed for the jawline. Most filler brands offer around six different firmness levels, allowing the cosmetic doctor to choose the most suitable one for each treatment.

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What Are the Differences Between Filler Brands?

Since the 1990s, we’ve made huge strides in the safety of fillers, but these days, improvements are naturally smaller. Most hyaluronic acid brands already have a high safety profile. However, it’s not something you can assume automatically. Worldwide, there are over 100 different manufacturers, with around 10 actively available in UK. These 10 brands are all reputable and well-established, yet there are still differences between them.To put it like cars: both an Opel and a Mercedes are safe, but one is generally perceived as more luxurious than the other.

Where are the subtle improvements today? Mainly in the purity of the hyaluronic acid and in the manufacturing techniques.
Read more:
What is Hyaluronic Acid?

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Which Filler Lasts the Longest?

In general, with hyaluronic acid fillers, softer fillers tend to provide shorter-lasting results than firmer ones. There is some flexibility—for example, using a slightly firmer lip filler can make the results last a little longer than with a very soft option.

The longevity also varies between brands due to differences in the manufacturing process. Manufacturers aim for fillers that last as long as possible, are minimally detectable, easy to inject (through a very fine cannula), and completely safe. To achieve this, they may adjust factors such as the level of cross-linking, purity, mixing, and how often the product is heated or cooled.

The most important factors are that your doctor uses a top-tier (A-brand) filler and selects the right variant for the specific treatment area.

Which Filler Brands Are There?

The following hyaluronic acid filler brands all have a strong reputation. These are often referred to as “A-Brand fillers”. This site especially highlights Belotero and Aliaxin.

Best Filler Brands

Years Active (in 2025)

Manufacturer

Country of Origin

Aliaxin

10+ years

IBSA Derma

Italy / Switzerland

Belotero

15+ years

Merz

Germany

Juvéderm

20+ years

Allergan (part of Abbvie)

France

Restylane

20+ years

Galderma

Sweden

Saypha

10+ years

Croma Pharma

Austria

Stylage

15+ years

Vivacy

France

Teosyal

15+ years

Teoxane

Switzerland

A-Brand Fillers

It’s essential to prioritise the safety of fillers. Fillers became popular in the 1990s, a time when there was very little clinical research and little was known about their long-term effects. Back then, permanent fillers were made from non-biodegradable, foreign materials. Over time, the body would reject these substances, often leading to serious complications. Since 1 January 2015, permanent fillers for cosmetic use have been legally banned in UK.

Since then, only biodegradable fillers have been permitted. Most of these are based on hyaluronic acid. Restylane, for example, is a hyaluronic acid filler brand that has been successfully used for over 20 years and has a strong safety profile. This long history has also allowed it to build a solid scientific foundation. Other brands have adopted similar techniques, making hyaluronic acid fillers safe when administered by trained professionals.

Read more:
Are Fillers Safe?

Best Hyaluronic Acid Filler Brands

The following hyaluronic acid fillers are used by doctors in UK. These are A-Brand fillers, all produced by reputable pharmaceutical companies, and are considered among the best brands worldwide. Each brand has its own characteristics. Which is the best filler brand? Click on the brand for more information:

Juvéderm
Restylane
Teosyal
Belotero
Stylage
Saypha
Aliaxin

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View Belotero reviews:

Op de academy dag heb ik mijn lippen voor de 5e keer binnen een jaar laten opvullen. Ik heb aangegeven dat de Belotero bij mij helaas snel verdwijnt. Samen met de arts en supervisor hebben we een plan gemaakt om te proberen te voorkomen dat de Belotero langer blijft zitten. Eerst zijn er 3D contouren met Belotero Intense ingebracht waardoor er al vollere lip... Show more »
Op de academy dag heb ik mijn lippen voor de 5e keer binnen een jaar laten opvullen. Ik heb aangegeven dat de Belotero bij mij helaas snel verdwijnt.
Samen met de arts en supervisor hebben we een plan gemaakt om te proberen te voorkomen dat de Belotero langer blijft zitten. Eerst zijn er 3D contouren met Belotero Intense ingebracht waardoor er al vollere lippen werden gecreëerd. Daarna volgde de “gewone” Belotero 1ml. Er is ruim de tijd genomen en het resultaat is veel mooier en anders dan de andere keren. Mijn omgeving zegt dit ook! Ik ben vooralsnog heel blij met het resultaat en hoop er nog lang van te kunnen genieten. Show less »
Chiara Alana
Faceland Utrecht
20 January 2023 13:01
Hyaluronic acid filler treatment
Hyaluronic acid filler treatment

Frequently asked questions about the best filler:

Which filler lasts the longest?

Which fillers are the best?

What are the safest fillers?

What is the best facial filler?

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